Depression in the Elderly: A Beta-Adrenergic Receptor Dysfunction?
| Autor: | Thomas J. Goldschmidt, Earl A. Burch |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Central Nervous System
Cerebral Cortex Iprindole Aging Depressive Disorder Hypothalamo-Hypophyseal System medicine.medical_specialty Adrenergic receptor business.industry Adaptation Physiological Adjustment Disorders Norepinephrine Psychiatry and Mental health Endocrinology Stress Physiological Internal medicine Receptors Adrenergic beta Humans Medicine Arousal business Depression (differential diagnoses) Aged |
| Zdroj: | The International Journal of Psychiatry in Medicine. 13:207-213 |
| ISSN: | 1541-3527 0091-2174 |
| Popis: | Depression is a significant problem in the elderly population and is often accompanied by cognitive changes and agitation. Hypothalamic-pituitary axis dysfunction may occur in some depressed elderly patients and represent a non-specific physiological hyperarousal state. Moreover, recent evidence confirms that antidepressants down-regulate beta-adrenergic receptors in the central nervous system. These findings provide the background for proposing that depression may result from an age-specific, stress-induced dysfunction of the beta-adrenergic receptor system in a subgroup of the geriatric population. A bio-psycho-social model for understanding and developing innovative treatment strategies for depression in the elderly is presented. |
| Databáze: | OpenAIRE |
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