Zinc Supplementation Restores Altered Biochemical Parameters in Stomach Tissue of STZ Diabetic Rats

Autor: Ismet Burcu Turkyilmaz, Bertan Boran Bayrak, Refiye Yanardag, Nuriye Akev, Ozgur Mutlu, Ozlem Sacan
Rok vydání: 2020
Předmět:
Blood Glucose
medicine.medical_specialty
Endocrinology
Diabetes and Metabolism
medicine.medical_treatment
Clinical Biochemistry
Intraperitoneal injection
Glutathione reductase
010501 environmental sciences
01 natural sciences
Biochemistry
Antioxidants
Diabetes Mellitus
Experimental
Inorganic Chemistry
Superoxide dismutase
03 medical and health sciences
chemistry.chemical_compound
Internal medicine
Diabetes mellitus
medicine
Animals
Xanthine oxidase
0105 earth and related environmental sciences
chemistry.chemical_classification
0303 health sciences
biology
Chemistry
Glutathione peroxidase
Stomach
030302 biochemistry & molecular biology
Biochemistry (medical)
General Medicine
Streptozotocin
medicine.disease
Zinc Sulfate
Rats
Oxidative Stress
Zinc
medicine.anatomical_structure
Endocrinology
Dietary Supplements
biology.protein
Female
medicine.drug
Zdroj: Biological Trace Element Research. 199:2259-2265
ISSN: 1559-0720
0163-4984
DOI: 10.1007/s12011-020-02352-z
Popis: The stomach is among the organs grossly affected organ by diabetic complications. The present study was aimed at investigating the protective role of zinc on stomach of streptozotocin (STZ)-induced diabetes mellitus. Female Swiss albino rats were divided in four experimental groups: Group I, control; group II, control + zinc sulfate; group III, STZ-induced diabetic animals; and group IV, STZ-diabetic + zinc sulfate. Diabetes was induced by intraperitoneal injection of STZ, at a dose of 65 mg/kg body weight. Zinc sulfate (100 mg/kg body weight) was given daily by gavage for 60 days to groups II and IV. At the end of the experiment, the rats were sacrificed, and the tissues were taken. In the diabetic group, hexose, hexosamine, fucose, and sialic acid levels, as well as tissue factor, adenosine deaminase, carbonic anhydrase, xanthine oxidase, lactate dehydrogenase, prolidase activities, advanced oxidized protein products, homocysteine, and TNF-α levels were increased in the stomach tissue homogenates. Whereas, catalase, superoxide dismutase, glutathione-S-transferase, glutathione peroxidase, glutathione reductase, paraoxonase, and aryl esterase activities were decreased in the diabetic group. The administration of zinc reversed all the deformities. These findings suggest that zinc has protective role in ameliorating several mechanisms of STZ-induced diabetic stomach injury.
Databáze: OpenAIRE
Externí odkaz: