The dengue virus nonstructural protein 1 (NS1) increases NF-κB transcriptional activity in HepG2 cells
| Autor: | Erna Geessien Kroon, Flávia G. G. Leite, Breno de Mello Silva, Lirlândia P. Sousa, Alessandra Cristina Gomes-Ruiz, Flávio Guimarães da Fonseca, Paulo César Peregrino Ferreira, Cláudio A. Bonjardim, Paulo Filemon Paolucci Pimenta, Mauro M. Teixeira |
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| Rok vydání: | 2011 |
| Předmět: |
Transcription
Genetic viruses Viral Nonstructural Proteins Dengue virus Biology medicine.disease_cause Virus Dengue Virology medicine Humans Antibody-dependent enhancement Lipid raft Host cell surface NS3 NF-kappa B virus diseases Hep G2 Cells General Medicine Dengue Virus biology.organism_classification Molecular biology Flavivirus Gene Expression Regulation Signal transduction |
| Zdroj: | Archives of Virology. 156:1275-1279 |
| ISSN: | 1432-8798 0304-8608 |
| DOI: | 10.1007/s00705-011-0969-0 |
| Popis: | Dengue virus nonstructural protein 1 (NS1) is a glycoprotein involved in viral RNA replication. NS1 associates with host cell proteins and can be found in lipid raft domains on the host cell surface, suggesting an involvement in signal transduction events. In this work, we observed that NS1 expression in HepG2 cells increases nuclear translocation of NF-κB p65 protein, which was paralleled by DNA-protein complex formation. Luciferase assays showed an increase in NF-κB transcriptional activities in NS1-expressing cells when compared to parental cells. NS1 may enhance NF-κB function in host cells and contribute to the pathogenesis of dengue. |
| Databáze: | OpenAIRE |
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