Data from acellular human heart matrix
| Autor: | Stefan M. Kren, Jaime Elízaga, Ricardo Sanz-Ruiz, Francisco Fernández-Avilés, Jesús Romero, Javier Bermejo, Mª Angeles González-Nicolas, Raquel Yotti, Hugo Rodríguez, Mª Angeles Espinosa, Pedro L. Sánchez, Judith R Acebes, Julio García, Ma Eugenia Fernandez-Santos, Doris A. Taylor, Salvatore Costanza, Candelas Pérez del Villar, Isabel Moscoso |
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| Přispěvatelé: | Ministerio de Ciencia e Innovación (España), Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), Centro de Investigación Biomédica en Red - CIBERCV (Enfermedades Cardiovasculares), Red de Terapia Celular (España), Comunidad de Madrid (España) |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Multidisciplinary Decellularization business.industry Cardiac muscle Human heart Structural integrity Anatomy Medicine and Dentistry lcsh:Computer applications to medicine. Medical informatics 03 medical and health sciences Coronary circulation 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Extracellular matrix scaffold 030220 oncology & carcinogenesis medicine Pressure volume lcsh:R858-859.7 business lcsh:Science (General) Perfusion Biomedical engineering lcsh:Q1-390 |
| Zdroj: | Repisalud Instituto de Salud Carlos III (ISCIII) Data in Brief, Vol 8, Iss, Pp 211-219 (2016) Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid Consejería de Sanidad de la Comunidad de Madrid Data in Brief |
| Popis: | Perfusion decellularization of cadaveric hearts removes cells and generates a cell-free extracellular matrix scaffold containing acellular vascular conduits, which are theoretically sufficient to perfuse and support tissue-engineered heart constructs. This article contains additional data of our experience decellularizing and testing structural integrity and composition of a large series of human hearts, "Acellular human heart matrix: a critical step toward whole heat grafts" (Sanchez et al., 2015) [1]. Here we provide the information about the heart decellularization technique, the valve competence evaluation of the decellularized scaffolds, the integrity evaluation of epicardial and myocardial coronary circulation, the pressure volume measurements, the primers used to assess cardiac muscle gene expression and, the characteristics of donors, donor hearts, scaffolds and perfusion decellularization process. This work was supported by grants from the Spanish Ministry of Science and Innovation (PLE2009–0152, PLE2009-147 and PLE2009-109) and the Instituto de Salud Carlos III (Ministry of Economy and Competitiveness, Spain: PI10–00141 and PI10-02038), Red de Investigación Cardiovacular (RIC) and Red de Terapia Celular (TerCel) from Instituto de Salud Carlos III (Ministry of Economy and Competitiveness, Spain) and Comunidad Autónoma de Madrid (CAM: S2010/BMD–2420). Salvatore Costanza was supported by PI10–00141; Mª Ángeles González de Nicolás were supported by PLE2009-0152; and Judith R Acebes was supported by PLE2009-0109. Sí |
| Databáze: | OpenAIRE |
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