Epileptic encephalopathy with electrical status epilepticus: An electroclinical study of 59 patients
| Autor: | Ayse Serdaroglu, A. Şebnem Soysal, Tugba Hirfanoglu, Ebru Arhan, Kürşad Aydın |
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| Jazyk: | angličtina |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Clobazam Clinical Neurology Status epilepticus Electroencephalography Symptomatic and idiopathic Neuropsychological aspects Epilepsy Status Epilepticus Refractory medicine Humans Longitudinal Studies Cognitive decline Child Neurologic Examination medicine.diagnostic_test business.industry Brain Infant General Medicine Epileptic encephalopathy with electrical status epilepticus during sleep medicine.disease Magnetic Resonance Imaging nervous system diseases Treatment Treatment Outcome nervous system Neurology Child Preschool Anesthesia Etiology Anticonvulsants Female Neurology (clinical) Levetiracetam medicine.symptom Sleep business medicine.drug |
| Zdroj: | Seizure. :86-93 |
| ISSN: | 1059-1311 |
| DOI: | 10.1016/j.seizure.2015.01.008 |
| Popis: | Purpose To evaluate the electroclinical features, treatment effectiveness, and outcome of 59 patients with epileptic encephalopathy with electrical status epilepticus during sleep. Methods Medical-files of 59 patients with electrical status epilepticus during sleep were retrospectively evaluated for data concerning: history, physical and neurological examinations, sleep and awake EEG's, psychometric tests and brain MRI. Results A total of 31 boys and 28 girls were identified. Patients were evaluated in two groups: symptomatic/structural and idiopathic group. There was no significant difference between the etiological groups in term of mean age at ESES onset, mean interval between the first seizure and the onset of ESES. The mean age at seizure onset was earlier in the symptomatic/structural group than the idiopathic ones. The mean follow-up time after the ESES onset was 4.5 years for all patients. The most effective antiepileptic drugs in our series were clobazam and levetiracetam. In refractory patients, steroid treatment was found effective during the early course of the disease. In the idiopathic group, cognitive decline has improved. However in the symptomatic group, patients did not respond to the treatment and cognitive deterioration did not improve in one third of the group. Conclusion The long-term outcome of ESES is highly variable and usually depends on etiology and the duration of ESES. The most efficious antiepileptic drugs in our study are clobazam and levetiracetam. |
| Databáze: | OpenAIRE |
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