Immune predictors of oral poliovirus vaccine immunogenicity among infants in South India
| Autor: | Gagandeep Kang, Nithya Jeyavelu, Sidhartha Giri, Srinivasan Venugopal, Saravanakumar Puthupalayam Kaliappan, Nisha Jose, Ira Praharaj, Yin-Huai Chen, Chanduni Syed, Jacob John, Nicholas C. Grassly, Edward P.K. Parker, Holm H. Uhlig, Beate Kampmann, Punithavathy Manickavasagam, Miren Iturriza-Gomara, Sudhir Babji |
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| Přispěvatelé: | Bill & Melinda Gates Foundation, Medical Research Council (MRC) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
lcsh:Immunologic diseases. Allergy Live attenuated vaccines Immunology CHILDREN Research & Experimental Medicine medicine.disease_cause Paediatric research lcsh:RC254-282 Article 03 medical and health sciences 0302 clinical medicine Immune system INFECTION medicine Pharmacology (medical) 030212 general & internal medicine DEVELOPING-COUNTRIES Seroconversion HUMAN ROTAVIRUS VACCINE Pharmacology Science & Technology Environmental enteropathy business.industry Poliovirus Immunogenicity GUT MICROBIOTA EFFICACY medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens DIARRHEA 3. Good health Vaccination Diarrhea 030104 developmental biology Infectious Diseases Medicine Research & Experimental Immunization VIRUS TRIAL medicine.symptom business lcsh:RC581-607 Life Sciences & Biomedicine NEWBORN |
| Zdroj: | Vaccines NPJ Vaccines npj Vaccines, Vol 5, Iss 1, Pp 1-8 (2020) |
| ISSN: | 2059-0105 |
| Popis: | Identification of the causes of poor oral vaccine immunogenicity in low-income countries might lead to more effective vaccines. We measured mucosal and systemic immune parameters at the time of vaccination with oral poliovirus vaccine (OPV) in 292 Indian infants aged 6–11 months, including plasma cytokines, leukocyte counts, fecal biomarkers of environmental enteropathy and peripheral blood T-cell phenotype, focused on gut-homing regulatory CD4+ populations. We did not find a distinct immune phenotype associated with OPV immunogenicity, although viral pathogens were more prevalent in stool at the time of immunization among infants who failed to seroconvert (63.9% vs. 45.6%, p = 0.002). Using a machine-learning approach, we could predict seroconversion a priori using immune parameters and infection status with a median 58% accuracy (cross-validation IQR: 50–69%) compared with 50% expected by chance. Better identification of immune predictors of OPV immunogenicity is likely to require sampling of mucosal tissue and improved oral poliovirus infection models. |
| Databáze: | OpenAIRE |
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