SRSF10: an atypical splicing regulator with critical roles in stress response, organ development, and viral replication
| Autor: | Benoit Chabot, Anna Salvetti, Lulzim Shkreta, Aurélie Delannoy |
|---|---|
| Přispěvatelé: | Faculté de médecine et des sciences de la santé [Sherbrooke] (UdeS), Université de Sherbrooke (UdeS), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre International de Recherche en Infectiologie - UMR (CIRI), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Salvetti, Anna |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Organogenesis
RNA-binding protein Cell Cycle Proteins [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC] Review Biology Virus Replication 03 medical and health sciences Splicing factor 0302 clinical medicine SR protein Stress Physiological [SDV.BC.BC] Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC] Humans Molecular Biology ComputingMilieux_MISCELLANEOUS 030304 developmental biology 0303 health sciences Serine-Arginine Splicing Factors Alternative splicing RNA 3. Good health Cell biology Repressor Proteins Alternative Splicing Viral replication RNA splicing 030217 neurology & neurosurgery Binding domain |
| Zdroj: | RNA RNA, In press, pp.rna.078879.121. ⟨10.1261/rna.078879.121⟩ RNA, Cold Spring Harbor Laboratory Press, In press, pp.rna.078879.121. ⟨10.1261/rna.078879.121⟩ |
| ISSN: | 1355-8382 1469-9001 |
| Popis: | Serine/arginine splicing factor 10 (SRSF10) is a member of the family of mammalian splicing regulators known as SR proteins. Like several of its SR siblings, the SRSF10 protein is composed of an RNA binding domain (RRM) and of arginine and serine-rich auxiliary domains (RS) that guide interactions with other proteins. The phosphorylation status of SRSF10 is of paramount importance for its activity and is subjected to changes during mitosis, heat-shock, and DNA damage. SRSF10 overexpression has functional consequences in a growing list of cancers. By controlling the alternative splicing of specific transcripts, SRSF10 has also been implicated in glucose, fat, and cholesterol metabolism, in the development of the embryonic heart, and in neurological processes. SRSF10 is also important for the proper expression and processing of HIV-1 and other viral transcripts. We discuss how SRSF10 could become a potentially appealing therapeutic target to combat cancer and viral infections. |
| Databáze: | OpenAIRE |
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