Adipose tissue attracts and protects acute lymphoblastic leukemia cells from chemotherapy
| Autor: | Brian Ichihara, Nora Heisterkamp, Steven D. Mittelman, Rocky Pramanik, Xia Sheng |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Cancer Research
Vincristine Daunorubicin Adipose tissue macrophages Adipose tissue Biology Article Mice chemistry.chemical_compound Cell Movement 3T3-L1 Cells Cell Line Tumor Adipocyte Tumor Microenvironment medicine Animals Humans Antibiotics Antineoplastic 3T3-L1 Hematology Precursor Cell Lymphoblastic Leukemia-Lymphoma Antineoplastic Agents Phytogenic Chemokine CXCL12 Transplantation Isogeneic Adipose Tissue Oncology chemistry Drug Resistance Neoplasm Cell culture Cancer research Neoplasm Transplantation medicine.drug Explant culture |
| Zdroj: | Leukemia Research. 37:503-509 |
| ISSN: | 0145-2126 |
| DOI: | 10.1016/j.leukres.2012.12.013 |
| Popis: | Obesity is associated with an increased risk of acute lymphoblastic leukemia (ALL) relapse. Using mouse and cell co-culture models, we investigated whether adipose tissue attracts ALL to a protective microenvironment. Syngeneically implanted ALL cells migrated into adipose tissue within ten days. In vitro, murine ALL cells migrated towards adipose tissue explants and 3T3-L1 adipocytes. Human and mouse ALL cells migrated toward adipocyte conditioned media, which was mediated by SDF-1α. In addition, adipose tissue explants protected ALL cells against daunorubicin and vincristine. Our findings suggest that ALL migration into adipose tissue could contribute to drug resistance and potentially relapse. |
| Databáze: | OpenAIRE |
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