Behavioral addictions in early-onset Parkinson disease are associated with DRD3 variants
| Autor: | Francesc Palau, Lydia Vela, Juan Carlos Martínez-Castrillo, Pedro J. Garcia-Ruiz, Carlos Martínez-García, Marina Mata, Janet Hoenicka, Cici Feliz-Feliz, Xochitl Helga Castro-Martínez, Irene Martinez-Torres |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Indoles media_common.quotation_subject Disease Polymorphism Single Nucleotide Dopamine agonist 03 medical and health sciences Pramipexole 0302 clinical medicine Dopamine receptor D3 Punding Internal medicine Humans Medicine Parkinson Age of Onset Aged media_common Genetic association DRD3 business.industry Addiction Dopaminergic Receptors Dopamine D3 Parkinson Disease Impulse control disorders Middle Aged Behavior Addictive Disruptive Impulse Control and Conduct Disorders 030104 developmental biology Ropinirole Neurology Dopamine Agonists Female Neurology (clinical) Geriatrics and Gerontology business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | PARKINSONISM & RELATED DISORDERS r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu Fundació Sant Joan de Déu r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF) r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF) Centro de Investigación Principe Felipe (CIPF) |
| ISSN: | 1353-8020 |
| Popis: | Background: Impulse control disorders (ICDs) comprise abnormal behaviors frequently found in patients with Parkinson's disease (PD) receiving antiparkinsonian medication. ICDs in PD would develop when dopaminergic treatment overstimulates the dopamine receptor D3 (DR3). Here we studied whether DR3 gene (DRD3) is associated to ICD in PD patients with early-onset (EOPD). Methods: We performed association analysis of the rs6280 DRD3 single nucleotide variation (SNV) (Ser9Gly) in a clinical sample of 126 non early-onset PD (NEOPD) and 73 EOPD (age at onset |
| Databáze: | OpenAIRE |
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