Values of SP-A protein in the nasal mucosa
| Autor: | S. Astore, Michele Loglisci, A. Cannatelli, Giulio Cesare Passali, Desiderio Passali, S. Boccuzzi, L. Bellussi |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Pulmonary Surfactant-Associated Protein A Reproducibility of Results 02 engineering and technology Middle Aged Sensitivity and Specificity Mucus Nasal Mucosa 03 medical and health sciences 0302 clinical medicine 020401 chemical engineering Otorhinolaryngology Humans Female Nasal Obstruction Sinusitis 0204 chemical engineering 030223 otorhinolaryngology Biomarkers Rhinitis |
| Zdroj: | HNO. 64:671-675 |
| ISSN: | 1433-0458 0017-6192 |
| Popis: | The paranasal sinus epithelium is exposed to the environment and therefore to a variety of biological, chemical and mechanical insults. Surfactant protein A (SP-A) is a 34-36 kD pulmonary surfactant-associated protein that appears to play an important role in mammalian first-line host defence. Recent studies have reported the possibility of local production of SP-A in the extrapulmonary organs and tissues of the human body. However, the presence of SP-A in the human paranasal sinus mucosa is not well known. The purpose of this study was to investigate the expression of SP-A protein in human turbinate mucosa and to compare the expression of SP-A mRNA in normal turbinate mucosa and turbinate mucosa of chronic rhinosinusitis patients. Reverse transcriptase polymerase chain reaction was used to detect SP-A mRNA. Student's t test was used for statistical comparison of the SP-A/GAPDH-mRNA ratio (GAPDH: glycerinaldehyde-3-phosphate dehydrogenase) of cases and controls. We found expression of SP-A mRNA in mucosa lining the inferior turbinates of healthy patients and its up-regulation in mucosa lining the inferior turbinates of patients with chronic rhinosinusitis. These results may provide targets for new therapies for chronic rhinosinusitis. |
| Databáze: | OpenAIRE |
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