GABAergic inhibition at dendrodendritic synapses tunes γ oscillations in the olfactory bulb
| Autor: | Samuel Lagier, Brice Bathellier, Pierre-Marie Lledo, Marco Sassoè-Pognetto, Jean-Marc Fritschy, Patrizia Panzanelli, Raúl E. Russo, Antoine Nissant |
|---|---|
| Přispěvatelé: | Perception et Mémoire, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Department of Anatomy, Pharmacology and Forensic Medicine, Università degli studi di Torino = University of Turin (UNITO), Neurofisiolgía Celulary Molecular, Instituto de Investigaciones Biológicas, Laboratory of Computational Neuroscience [Lausanne] (LCN-EPFL), Ecole Polytechnique Fédérale de Lausanne (EPFL)-Brain and Mind Institute, Istituto Nazionale di Neuroscienze, Institute of Pharmacology and Toxicology [Zurich], Universität Zürich [Zürich] = University of Zurich (UZH), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Università degli studi di Torino (UNITO) |
| Rok vydání: | 2007 |
| Předmět: |
MESH: Olfactory Bulb
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Models Neurological MESH: gamma-Aminobutyric Acid Biology Neurotransmission MESH: Dendrites MESH: Phenotype Inhibitory postsynaptic potential gamma-Aminobutyric acid MESH: Synapses GABAA-rho receptor Synapse Mice 03 medical and health sciences 0302 clinical medicine MESH: Models Neurological medicine Animals MESH: Animals α1 knockout GABAA receptor olfaction reciprocal synapses Receptor MESH: Mice MESH: Receptors GABA-A MESH: Inhibitory Postsynaptic Potentials gamma-Aminobutyric Acid 030304 developmental biology 0303 health sciences Multidisciplinary Glutamate receptor Dendrites Anatomy Biological Sciences Receptors GABA-A Olfactory Bulb Olfactory bulb Phenotype Inhibitory Postsynaptic Potentials Synapses Biophysics 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America Proceedings of the National Academy of Sciences of the United States of America, 2007, 104 (17), pp.7259-64. ⟨10.1073/pnas.0701846104⟩ Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2007, 104 (17), pp.7259-64. ⟨10.1073/pnas.0701846104⟩ |
| ISSN: | 1091-6490 0027-8424 |
| Popis: | In the olfactory bulb (OB), odorants induce oscillations in the γ range (20–80 Hz) that play an important role in the processing of sensory information. Synaptic transmission between dendrites is a major contributor to this processing. Glutamate released from mitral cell dendrites excites the dendrites of granule cells, which in turn mediate GABAergic inhibition back onto mitral cells. Although this reciprocal synapse is thought to be a key element supporting oscillatory activity, the mechanisms by which dendrodendritic inhibition induces and maintains γ oscillations remain unknown. Here, we assessed the role of the dendrodendritic inhibition, using mice lacking the GABA A receptor α1-subunit, which is specifically expressed in mitral cells but not in granule cells. The spontaneous inhibitory postsynaptic current frequency in these mutants was low and was consistent with the reduction of GABA A receptor clusters detected by immunohistochemistry. The remaining GABA A receptors in mitral cells contained the α3-subunit and supported slower decaying currents of unchanged amplitude. Overall, inhibitory-mediated interactions between mitral cells were smaller and slower in mutant than in WT mice, although the strength of sensory afferent inputs remained unchanged. Consequently, both experimental and theoretical approaches revealed slower γ oscillations in the OB network of mutant mice. We conclude, therefore, that fast oscillations in the OB circuit are strongly constrained by the precise location, subunit composition and kinetics of GABA A receptors expressed in mitral cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|