The anti-tumor activities of interferon (IFN)-α in chronic myelogenous leukaemia (CML)-derived cell lines depends on the IFN-α subtypes
| Autor: | Osamu Sanou, Kouzou Yamamoto, Masashi Kurimoto, Yoshiaki Yanai, Hiroshi Yamauchi, Hakuo Ikegami |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Cancer Research
Fas Ligand Protein medicine.medical_treatment Cell Genes MHC Class I Alpha interferon Antineoplastic Agents Apoptosis Interferon alpha-2 Biology Myelogenous HLA Antigens Interferon Leukemia Myelogenous Chronic BCR-ABL Positive Tumor Cells Cultured medicine Humans Immunologic Factors fas Receptor Interferon alfa Membrane Glycoproteins Gene Expression Regulation Leukemic Interferon-alpha U937 Cells medicine.disease Recombinant Proteins Neoplasm Proteins Leukemia medicine.anatomical_structure Cytokine Oncology Cell culture Interferon Type I Immunology Interferons Cell Division medicine.drug |
| Zdroj: | Cancer Letters. 185:173-179 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/s0304-3835(02)00277-x |
| Popis: | Here we report on the anti-tumor effects of five interferon (IFN)-alpha subtypes, alpha1, alpha2, alpha5, alpha8, and alpha10 in chronic myelogenous leukaemia (CML)-derived cell lines. All of the CML cells can respond to IFN-alpha although the anti-tumor effects of IFN-alpha depend on the target cell and on the type of IFN-alpha subtype used. Proliferation assays showed that IFN-alpha8 was substantially more effective than the other four IFN-alpha subtypes. IFN-alpha8 was the most potent at upregulating immunomodulatory molecule expression while IFN-alpha1 was least potent. These data indicate in vitro distinctions between IFN-alpha subtypes that should be appreciated more in the clinic. |
| Databáze: | OpenAIRE |
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