CD4+ T Cells Require Either B Cells or CD8+ T Cells to Control Spread and Pathogenesis of a Neurotropic Infection
| Autor: | Glenn F. Rall, Andreas C. Solomos, Kevin J. O'Regan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
CD4-Positive T-Lymphocytes Male Biology CD8-Positive T-Lymphocytes Article 03 medical and health sciences Interleukin 21 Mice Immune system Immunity Virology medicine Cytotoxic T cell Animals Humans B cell B-Lymphocytes Virulence Brain Acquired immune system Mice Inbred C57BL Viral Tropism 030104 developmental biology medicine.anatomical_structure Viral replication Measles virus Immunology Female CD8 Measles |
| Popis: | Immunity within the brain, specifically to virus-infected neurons, must be controlled to prevent neuron loss and impairment, though the process by which this occurs remains unclear. Here, we use a mouse model of neuron-restricted measles virus infection, in which immunocompetent adults survive challenge, whereas T and B cell-deficient mice succumb. This model allowed us to more precisely define the contributions of CD4+ T cells, CD8+ T cells, and B cells in neuroprotection. Both B cell knockout mice and mice depleted of CD8+ T cells survive challenge and show no signs of illness, though are less able to control viral replication than immunocompetent mice. In contrast, depletion of CD4+ T cells results in disease and death in all infected mice, though the kinetics of illness are delayed compared to RAG knockout mice. Our data suggest a coordinated interplay of adaptive immune components, which collectively controls viral spread and limits neuropathogenesis. |
| Databáze: | OpenAIRE |
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