10-Hydroxydecanoic Acid Potentially Elicits Antigen-Specific IgA Responses
| Autor: | Ayumi Kuratani, Nobutoki Takamune, Tatsuya Isayama, Toshimasa Takasaki, Shogo Misumi, Naoki Kishimoto, Hikaru Etoh, Tomoki Tatefuji, Tomoki Ikuta, Yoshihiro Takahashi, Atsunobu Muneoka |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Immunoglobulin A Male Pharmaceutical Science 03 medical and health sciences 0302 clinical medicine Immune system Antigen medicine Animals Humans Antigens Intestinal Mucosa Receptor Immunity Mucosal Microfold cell Pharmacology biology RANK Ligand Cell Differentiation Epithelial Cells General Medicine Epithelium Macaca fascicularis 030104 developmental biology medicine.anatomical_structure Lymphatic system Transcytosis 030220 oncology & carcinogenesis Immunology biology.protein Caco-2 Cells Decanoic Acids |
| Zdroj: | Biologicalpharmaceutical bulletin. 43(8) |
| ISSN: | 1347-5215 |
| Popis: | The effective antigen (Ag) uptake by microfold cells (M-cells) is important for the induction of an efficient mucosal immune responses. Here, we show that 10-hydroxydecanoic acid (10-HDAA) from royal jelly (RJ) potentially supports M-cell differentiation and induces effective antigen-specific mucosal immune responses in cynomolgus macaques. 10-HDAA increases the expression level of receptor activator of nuclear factor-kappaB (NF-κB) (RANK) in Caco-2 cells, which suggests that 10-HDAA potentially prompts the differentiation of Caco-2 cells into M-cells and increased transcytosis efficiency. This idea is supported by the following observations. Intranasal administration of 10-HDAA increased the number of M-cells in the epithelium overlying nasopharynx-associated lymphoid tissue (NALT) in macaques. Oral administration of 10-HDAA increased the number of M-cells in the follicle-associated epithelium (FAE) covering Peyer's patches (PPs) and significantly increased the antigen-specific immunoglobulin A (IgA) level in macaques. These findings suggest that the exogenous honeybee-derived medium-chain fatty acid 10-HDAA may effectively enhance antigen-specific immune responses. |
| Databáze: | OpenAIRE |
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