Functional network dynamics in a neurodevelopmental disorder of known genetic origin
| Autor: | Duncan E. Astle, Diandra Brkić, Kate Baker, Mengya Zhang, Mark W. Woolrich, Danyal Akarca, Erin Hawkins |
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| Přispěvatelé: | Brkić, Diandra [0000-0001-5521-8232], Apollo - University of Cambridge Repository |
| Rok vydání: | 2021 |
| Předmět: |
magnetoencephalography
Male Brain activity and meditation Gene Expression 0302 clinical medicine Neurodevelopmental disorder Intellectual disability Cognitive development atypical brain development Attention Hidden Markov model Research Articles Cerebral Cortex 0303 health sciences Radiological and Ultrasound Technology medicine.diagnostic_test 05 social sciences Cognition Markov Chains Neurology Auditory Perception Anatomy Research Article cognitive development Adult Adolescent human genetics Biology 050105 experimental psychology 03 medical and health sciences Young Adult Intellectual Disability Genetic variation medicine Connectome Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Association (psychology) 030304 developmental biology functional connectivity Magnetoencephalography Neurophysiology medicine.disease Network dynamics Neurology (clinical) Nerve Net Neuroscience 030217 neurology & neurosurgery Acyltransferases |
| Zdroj: | Human Brain Mapping |
| DOI: | 10.17863/cam.63144 |
| Popis: | Dynamic connectivity in functional brain networks is a fundamental aspect of cognitive development, but we have little understanding of the mechanisms driving variability in these networks. Genes are likely to influence the emergence of fast network connectivity via their regulation of neuronal processes, but novel methods to capture these rapid dynamics have rarely been used in genetic populations. The current study redressed this by investigating brain network dynamics in a neurodevelopmental disorder of known genetic origin, by comparing individuals with a ZDHHC9‐associated intellectual disability to individuals with no known impairment. We characterised transient network dynamics using a Hidden Markov Model (HMM) on magnetoencephalography (MEG) data, at rest and during auditory oddball stimulation. The HMM is a data‐driven method that captures rapid patterns of coordinated brain activity recurring over time. Resting‐state network dynamics distinguished the groups, with ZDHHC9 participants showing longer state activation and, crucially, ZDHHC9 gene expression levels predicted the group differences in dynamic connectivity across networks. In contrast, network dynamics during auditory oddball stimulation did not show this association. We demonstrate a link between regional gene expression and brain network dynamics, and present the new application of a powerful method for understanding the neural mechanisms linking genetic variation to cognitive difficulties. |
| Databáze: | OpenAIRE |
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