Fecal Fusobacterium nucleatum as a predictor for metachronous colorectal adenoma after endoscopic polypectomy
| Autor: | Si-Yuan Pan, Ying-Xuan Chen, Jin-Hui Xue, Yuan-Hong Xie, Yun Qian, Jing-Yuan Fang, Tian-Xue Xia, Zi-Ran Kang, Cheng-Bei Zhou, Tian-Hui Zou |
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| Rok vydání: | 2021 |
| Předmět: |
Adenoma
medicine.medical_specialty Colorectal cancer medicine.medical_treatment Colonic Polyps Colorectal adenoma Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Prospective Studies Risk factor Prospective cohort study Retrospective Studies Hepatology Fusobacterium nucleatum business.industry Retrospective cohort study Odds ratio medicine.disease Polypectomy stomatognathic diseases 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology business Colorectal Neoplasms |
| Zdroj: | Journal of gastroenterology and hepatologyReferences. 36(10) |
| ISSN: | 1440-1746 |
| Popis: | BACKGROUND AND AIM Fusobacterium nucleatum is increasingly being recognized as an important risk factor in colorectal cancer and colorectal adenoma. Endoscopic polypectomy is associated with a decreased incidence of colorectal cancer; however, patients still suffer from a risk of metachronous adenoma. Currently, there are few effective non-invasive factors that may predict metachronous colorectal adenoma. Here, we evaluated the performance of F. nucleatum in predicting metachronous adenoma. METHODS Fecal samples and clinical information of patients before endoscopic polypectomy were collected from 367 patients in a retrospective cohort, and 238 patients in a prospective cohort. The abundance of fecal F. nucleatum was measured via quantitative polymerase chain reaction. Surveillance colonoscopies were conducted between 1 and 3 years after polypectomy (average follow-up 27.07 months for the retrospective cohort & 22.57 months for the prospective cohort) to identify metachronous adenoma. Candidate predictive factors and cut-off value of F. nucleatum abundance were identified from the retrospective cohort and then validated in the prospective cohort. RESULTS A high abundance of fecal F. nucleatum was found to be an independent risk factor for metachronous adenomas (odds ratio, 6.38; P |
| Databáze: | OpenAIRE |
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