Primordial odontogenic tumor: Subepithelial expression of Syndecan-1 and Ki-67 suggests origin during early odontogenesis
| Autor: | Ronell Bologna-Molina, F R Pires, Vanesa Pereira-Prado, Gabriel Tapia-Repetto, Roman Carlos, Toshinari Mikami, Adalberto Mosqueda-Taylor |
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| Rok vydání: | 2017 |
| Předmět: |
Pathology
medicine.medical_specialty Proliferation index Population Connective tissue Odontogenic Tumors Biology Syndecan 1 Extracellular matrix Mesoderm 03 medical and health sciences 0302 clinical medicine medicine Humans Dental papilla education General Dentistry Cell Proliferation Retrospective Studies education.field_of_study Enamel organ Odontogenic tumor Tooth Germ 030206 dentistry medicine.disease medicine.anatomical_structure Ki-67 Antigen Otorhinolaryngology 030220 oncology & carcinogenesis Odontogenesis Syndecan-1 |
| Zdroj: | Oral diseases. 24(1-2) |
| ISSN: | 1601-0825 |
| Popis: | Primordial odontogenic tumor (POT) is composed of variably cellular myxoid connective tissue, surrounded by cuboidal to columnar odontogenic epithelium resembling the inner epithelium of the enamel organ, which often invaginates into the underlying connective tissue. The tumor is delimited at least partially by a thin fibrous capsule. It derives from the early stages of tooth development. Syndecan-1 is a heparan sulfate proteoglycan that has a physiological role in several cellular functions, including maintenance of the epithelial architecture, cell-to-cell adhesion and interaction of cells with extracellular matrix, and with diverse growth factors, stimulating cell proliferation. Ki-67 is considered the gold standard as a cell proliferation marker. The aim of this study was to examine the expression of Syndecan-1 and Ki-67 proliferation index in POT and normal tooth germs to better understand the biological behavior of this tumor. Results showed that Syndecan-1 was more intensely expressed in subepithelial mesenchymal areas of POT, in a pattern that resembles the early stages of tooth development. The cell proliferation index (4.1%) suggests that POT is a slow growing tumor. Syndecan-1 expression in tooth germs in late cap and early bell stages was similar to POT, showing immunopositivity in subepithelial mesenchymal condensed areas. The immunohistochemical findings showed a pattern in which the population of subepithelial mesenchymal cells exhibited greater proliferative activity than the central portion of the dental papilla. |
| Databáze: | OpenAIRE |
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