Multi-systemic alterations by chronic exposure to a low dose of bisphenol a in drinking water: Effects on inflammation and nad+-dependent deacetylase sirtuin1 in lactating and weaned rats

Autor: Paola Di Pietro, Silvia Fasano, Marianna Marino, Carmine Vecchione, Jacopo Troisi, Antonietta Santoro, Donato Cappetta, Rosaria Meccariello, Elena Mele, Antonella De Angelis, Orlando Paciello, Andrea Viggiano, Riccardo Pierantoni, Marika Scafuro, Giuseppe Piegari
Přispěvatelé: Santoro, A., Scafuro, M., Troisi, J., Piegari, G., Di Pietro, P., Mele, E., Cappetta, D., Marino, M., De Angelis, A., Vecchione, C., Paciello, O., Fasano, S., Pierantoni, R., Viggiano, A., Meccariello, R.
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Microvesicular Steatosis
Adipose tissue
cerebral ventricles
Sirtuin 1
Pregnancy
Lactation
Water Pollutants
Biology (General)
Spectroscopy
Benzhydryl Compound
Sirt1
biology
Epigenetic
General Medicine
Cerebral ventricle
Immunohistochemistry
BPA
Computer Science Applications
Chemistry
Sirt1-AS LncRNA
medicine.anatomical_structure
Adipose Tissue
Toxicity
Gestation
Female
Health Impact Assessment
medicine.symptom
hormones
hormone substitutes
and hormone antagonists
medicine.medical_specialty
endocrine system
QH301-705.5
Inflammation
Chemical
Weaning
liver
Catalysis
Article
Proinflammatory cytokine
Inorganic Chemistry
Phenols
Internal medicine
medicine
Animals
Physical and Theoretical Chemistry
Benzhydryl Compounds
Molecular Biology
QD1-999
epigenetics
inflammation
Phenol
business.industry
urogenital system
Animal
Drinking Water
Organic Chemistry
Oxidative Stre
Cerebral ventricles
Epigenetics
Liver
Disease Models
Animal
Environmental Exposure
NAD
Oxidative Stress
Rats
Water Pollutants
Chemical
Endocrinology
Disease Models
biology.protein
Rat
business
Zdroj: International Journal of Molecular Sciences
Volume 22
Issue 18
International Journal of Molecular Sciences, Vol 22, Iss 9666, p 9666 (2021)
Popis: Bisphenol A (BPA) is largely used as a monomer in some types of plastics. It accumulates in tissues and fluids and is able to bypass the placental barrier, affecting various organs and systems. Due to huge developmental processes, children, foetuses, and neonates could be more sensitive to BPA-induced toxicity. To investigate the multi-systemic effects of chronic exposure to a low BPA dose (100 μg/L), pregnant Wistar rats were exposed to BPA in drinking water during gestation and lactation. At weaning, newborn rats received the same treatments as dams until sex maturation. Free and conjugated BPA levels were measured in plasma and adipose tissue
the size of cerebral ventricles was analysed in the brain
morpho-functional and molecular analyses were carried out in the liver with a focus on the expression of inflammatory cytokines and Sirtuin 1 (Sirt1). Higher BPA levels were found in plasma and adipose tissue from BPA treated pups (17 PND) but not in weaned animals. Lateral cerebral ventricles were significantly enlarged in lactating and weaned BPA-exposed animals. In addition, apart from microvesicular steatosis, liver morphology did not exhibit any statistically significant difference for morphological signs of inflammation, hypertrophy, or macrovesicular steatosis, but the expression of inflammatory cytokines, Sirt1, its natural antisense long non-coding RNA (Sirt1-AS LncRNA) and histone deacetylase 1 (Hdac1) were affected in exposed animals. In conclusion, chronic exposure to a low BPA dose could increase the risk for disease in adult life as a consequence of higher BPA circulating levels and accumulation in adipose tissue during the neonatal period.
Databáze: OpenAIRE
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