Nanostructured systems containing babassu (Orbignya speciosa) oil as a potential alternative therapy for benign prostatic hyperplasia
| Autor: | Carlos Rangel Rodrigues, Lidia Tajber, Fabio Boylan, Lucio Mendes Cabral, Vinícius Raphael de Almeida Borges, Joanne Crean, Valeria Pereira de Sousa |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Thermogravimetric analysis
congenital hereditary and neonatal diseases and abnormalities Materials science poly(lactic-co-glycolic acid) Dispersity Biophysics Pharmaceutical Science Nanoparticle Bioengineering Arecaceae Nanocomposites Biomaterials chemistry.chemical_compound Polylactic Acid-Polyglycolic Acid Copolymer International Journal of Nanomedicine Drug Discovery medicine Zeta potential Organic chemistry Plant Oils Lactic Acid Original Research benign prostatic hyperplasia Nanocomposite Polyvinylpyrrolidone nanocomposite treatment nanotechnology babassu oil Organic Chemistry General Medicine Babassu oil PLGA chemistry nanoparticles Polyglycolic Acid Nuclear chemistry medicine.drug |
| Zdroj: | International Journal of Nanomedicine |
| ISSN: | 1178-2013 1176-9114 |
| Popis: | Valeria Pereira de Sousa,1 Joanne Crean,2 Vinícius Raphael de Almeida Borges,1 Carlos Rangel Rodrigues,1 Lidia Tajber,2 Fabio Boylan,2 Lucio Mendes Cabral1 1Department of Pharmaceutics, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; 2School of Pharmacy and Pharmaceutical Sciences and Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland Abstract: The oil of babassu tree nuts (Orbignya speciosa) is a potential alternative for treatment and prophylaxis of benign prostatic hyperplasia. Improved results can be obtained by drug vectorization to the hyperplastic tissue. The main objective of this work was the preparation and characterization of poly(lactic-co-glycolic acid) (PLGA) nanoparticle and clay nanosystems containing babassu oil (BBS). BBS was extracted from the kernels of babassu tree nuts and characterized by gas chromatography-mass spectrometry as well as 1H and 13C nuclear magnetic resonance. BBS-clay nanosystems were obtained by adding polyvinylpyrrolidone, Viscogel B8®, and BBS at a 2:1:1 mass ratio and characterized by X-ray diffraction, thermogravimetric analysis, infrared spectroscopy, and laser diffraction. The PLGA-BBS nanoparticles were prepared by the precipitation-solvent evaporation method. Mean diameter, polydispersity, zeta potential, and scanning electron microscopic images of the nanosystems were analyzed. Thermogravimetric analysis showed successful formation of the nanocomposite. PLGA nanoparticles containing BBS were obtained, with a suitable size that was confirmed by scanning electron microscopy. Both nanostructured systems showed active incorporation yields exceeding 90%. The two systems obtained represent a new and potentially efficient therapy for benign prostatic hyperplasia. Keywords: babassu oil, nanocomposite, poly(lactic-co-glycolic acid), nanoparticles, benign prostatic hyperplasia, treatment, nanotechnology |
| Databáze: | OpenAIRE |
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