Structural studies of DNA end detection and resection in homologous recombination
| Autor: | Karl-Peter Hopfner, Florian Seifert, Christian B. Schiller, Christian Linke-Winnebeck |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Genetics
biology DNA Repair Models Genetic DNA repair DNA damage Helicase Computational biology Genetic recombination General Biochemistry Genetics and Molecular Biology Non-homologous end joining chemistry.chemical_compound Microhomology-mediated end joining chemistry PERSPECTIVES biology.protein Humans DNA Breaks Double-Stranded Homologous recombination Homologous Recombination DNA Signal Transduction |
| Zdroj: | Cold Spring Harbor Perspectives in Biology |
| ISSN: | 1943-0264 |
| Popis: | DNA double-strand breaks are repaired by two major pathways, homologous recombination or nonhomologous end joining. The commitment to one or the other pathway proceeds via different steps of resection of the DNA ends, which is controlled and executed by a set of DNA double-strand break sensors, endo- and exonucleases, helicases, and DNA damage response factors. The molecular choreography of the underlying protein machinery is beginning to emerge. In this review, we discuss the early steps of genetic recombination and double-strand break sensing with an emphasis on structural and molecular studies. |
| Databáze: | OpenAIRE |
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