Fundamentals of Ion Mobility-Mass Spectrometry for the Analysis of Biomolecules
| Autor: | Jody C. May, James C Poland, John A. McLean, Caleb B. Morris |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Proteomics Computer science Ion-mobility spectrometry Biomolecule 010401 analytical chemistry Chemical biology Nanotechnology Context (language use) Genomics History 20th Century 010402 general chemistry Mass spectrometry 01 natural sciences History 21st Century Article 0104 chemical sciences Metabolomics chemistry Health informatics tools Ion Mobility Spectrometry Humans |
| Zdroj: | Methods Mol Biol Methods in Molecular Biology ISBN: 9781071600290 |
| Popis: | Ion mobility-mass spectrometry (IM-MS) combines complementary size- and mass-selective separations into a single analytical platform. This chapter provides context for both the instrumental arrangements and key application areas that are commonly encountered in bioanalytical settings. New advances in these high-throughput strategies are described with description of complementary informatics tools to effectively utilize these data-intensive measurements. Rapid separations such as these are especially important in systems, synthetic, and chemical biology in which many small molecules are transient and correspond to various biological classes for integrated omics measurements. This chapter highlights the fundamentals of IM-MS and its applications toward biomolecular separations and discusses methods currently being used in the fields of proteomics, lipidomics, and metabolomics. |
| Databáze: | OpenAIRE |
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