Pyk2 level is a novel prognostic marker for patients with esophageal squamous cell carcinoma after radical surgery
| Autor: | Bo Cai, Zhuolin Chen, Qiuxing Yang, Jingjing Shao, Tong Zhu, Guoxin Mao |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Esophageal Neoplasms Apoptosis Pathology and Forensic Medicine Western blot Cell Movement Cell Line Tumor medicine Biomarkers Tumor Humans Neoplasm Invasiveness Radical surgery Molecular Biology Protein kinase B Aged Cell Proliferation Neoplasm Staging Cisplatin Tissue microarray medicine.diagnostic_test Akt/PKB signaling pathway business.industry Cell Biology General Medicine Middle Aged digestive system diseases Esophagectomy Focal Adhesion Kinase 2 Treatment Outcome Tumor progression Cancer research Immunohistochemistry Female Esophageal Squamous Cell Carcinoma business Proto-Oncogene Proteins c-akt medicine.drug Signal Transduction |
| Zdroj: | Virchows Archiv : an international journal of pathology. 479(5) |
| ISSN: | 1432-2307 |
| Popis: | Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors in East Asia. Surgical resection is currently the typical treatment. However, due to the highly invasive and metastatic characteristic of the disease, the mortality rate is still high. A search for potential prognostic biomarkers and therapeutic targets is very necessary. Here, we studied the expression of proline-rich tyrosine kinase 2 (Pyk2), a non-receptor tyrosine protein kinase, in ESCC and its influence on prognosis. A total of 112 cases of ESCC and paired adjacent normal tissues (NT) were organized in tissue microarray (TMA) from the Nantong First People’s Hospital. Our analysis of TMA revealed that Pyk2 levels were higher in ESCC than in paired adjacent NT by immunohistochemistry (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink