Impact of the circadian clock on fibrinolysis and coagulation in healthy individuals and cardiovascular patients – A systematic review

Autor:	M.I. Schønsted, A.S. West, Helle K. Iversen
Rok vydání:	2021
Předmět:	Circadian rhythm Suprachiasmatic nucleus business.industry Fibrinolysis medicine.medical_treatment Circadian clock Physiology Thrombosis Endogeny Hematology Cardiovascular disease medicine.disease Hypercoagulable states Rhythm medicine business Morning
Zdroj:	West, A S, Schønsted, M I & Iversen, H K 2021, ' Impact of the circadian clock on fibrinolysis and coagulation in healthy individuals and cardiovascular patients – A systematic review ', Thrombosis Research, vol. 207, pp. 75-84 . https://doi.org/10.1016/j.thromres.2021.09.011
ISSN:	0049-3848
DOI:	10.1016/j.thromres.2021.09.011
Popis:	Introduction Human body functions exhibit a circadian rhythm generated in peripheral cells and synchronized by the suprachiasmatic nucleus (SCN), which mostly is entrained by the daily light/dark cycles. Activity, meals and posture are capable of interfering with the endogenous circadian rhythm of coagulation parameters. An increasing number of human disorders show a circadian component, and epidemiological studies find cardiovascular events to peak in the morning hours. The aim was to review the circadian rhythms impact on fibrinolysis and coagulation in healthy individuals and cardiovascular patients. Materials and methods A total number of 25 studies were identified where 8 enrolled cardiovascular patients with or without healthy individuals. Using a MeSH-search in MEDLINE PubMed. Only original peer-reviewed papers were included. Results Results showed substantial variance with respect to exhibition of circadian rhythms and/or peak/trough times. Circadian rhythms of fibrinolysis were less pronounced in cardiovascular patients than in healthy individuals with decreased levels in the morning hours compared to healthy inducing higher risk of blood clotting. Conclusions Because of small studied group sizes and failure to control for entraining factors, larger studies are needed to fully establish the effects of the circadian rhythm on especially coagulation. The findings of chronobiologic rhythms in coagulation and fibrinolysis could suggest a need for a chrono-pharmacological approach when treating/preventing cardiovascular diseases.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f47dea0cdd66a1ccced56808c10f2aa8 https://doi.org/10.1016/j.thromres.2021.09.011 Zobrazit plný text záznamu Full Text from ScienceDirect