Clinical Features and Risk of Relapse in Children and Adults with Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease

Autor: Mikael Cohen, Anne Lepine, Françoise Durand-Dubief, Bertrand Audoin, Mar Tintoré, Eric Thouvenot, Jonathan Ciron, Romain Marignier, Anne Ruiz, Kumaran Deiva, Jérôme De Seze, Philippe Horello, Alvaro Cobo-Calvo, Alexis Montcuquet, Caroline Papeix, Hélène Zéphir, Romain Deschamps, Sandra Vukusic, Hélène Maurey, Nicolas Collongues, Elisabeth Maillart, Pierre Labauge, Bertrand Bourre, Pierre Meyer, Damien Biotti, Georgina Arrambide, Fabien Rollot, Xavier Ayrignac
Přispěvatelé: Neurological Hospital Pierre Wertheimer, Vall d'Hebron University Hospital [Barcelona], Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Fondation Eugène Devic EDMUS, Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Service de pédiatrie spécialisée et médecine infantile (neurologie, pneumologie, maladies héréditaires du métabolisme) [Hôpital de la Timone - APHM], Hôpital de la Timone [CHU - APHM] (TIMONE), Service de neurologie [Le Kremlin Bicêtre], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, Lille Neurosciences & Cognition - U 1172 (LilNCog), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Département Neurologie [CHU Toulouse], Pôle Neurosciences [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), CIC, INSERM 1434, University Hospital of Strasbourg, Strasbourg, France, Département de neurologie [Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [CHU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université de Montpellier (UM), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Service de Neurologie [CHU Nimes] (Pôle NIRR), Hôpital Universitaire Carémeau [Nîmes] (CHU Nîmes), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Service de neurologie [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU), Service de Neurologie [CHU Limoges], CHU Limoges, Service de Neurologie [CHU Nice], Hôpital Pasteur [Nice] (CHU)-Centre Hospitalier Universitaire de Nice (CHU Nice), Immunologie des Maladies Virales et Autoimmunes (IMVA - U1184), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Clinical Investigation Center, Inserm U1434, university hospital of Strasbourg, Hospices Civils de Lyon, Departement de Neurologie (HCL)
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Adult
Male
0301 basic medicine
medicine.medical_specialty
Optic Neuritis
Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC]
Adolescent
[SDV]Life Sciences [q-bio]
Myelin oligodendrocyte glycoprotein
Young Adult
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
Humans
Medicine
Optic neuritis
Young adult
10. No inequality
ComputingMilieux_MISCELLANEOUS
Autoantibodies
Aquaporin 4
Expanded Disability Status Scale
biology
business.industry
Proportional hazards model
[SCCO.NEUR]Cognitive science/Neuroscience
Hazard ratio
Age Factors
medicine.disease
Confidence interval
3. Good health
030104 developmental biology
Neurology
Chronic Disease
Acute disseminated encephalomyelitis
Disease Progression
biology.protein
Female
Myelin-Oligodendrocyte Glycoprotein
Neurology (clinical)
business
030217 neurology & neurosurgery
Zdroj: Annals of Neurology
Annals of Neurology, In press, 89, pp.30-41. ⟨10.1002/ana.25909⟩
Annals of Neurology, Wiley, In press, ⟨10.1002/ana.25909⟩
ISSN: 0364-5134
1531-8249
DOI: 10.1002/ana.25909⟩
Popis: OBJECTIVE: The main objective was to compare clinical features, disease course, and myelin oligodendrocyte glycoprotein (MOG) antibody (Ab) dynamics between children and adults with MOG-Ab-associated disease (MOGAD). METHODS: This retrospective multicentric, national study included 98 children and 268 adults with MOGAD between January 2014 and September 2019. Cox regression model for recurrent time-to-event data and Kaplan-Meier curves for time to antibody negativity were performed for the objectives. RESULTS: Isolated optic neuritis was the most frequent clinical presentation in both children (40.8%) and adults (55.9%, p = 0.013), and acute disseminated encephalomyelitis syndrome was more frequent in children (36.7% vs 5.6%, p
Databáze: OpenAIRE
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