Comparison of virological profiles of respiratory syncytial virus and rhinovirus in acute lower tract respiratory infections in very young Chilean infants, according to their clinical outcome

Autor: Jonás Chnaiderman, Jorge Levican, M. Angélica Palomino, Aldo Gaggero, Carmen E. Larrañaga, Vivian Luchsinger, Sandra Ampuero
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Male
ALTRI
acute low tract respiratory infection
Rhinovirus
viruses
Respiratory syncytial virus
medicine.disease_cause
Gastroenterology
Nasopharynx
Medicine
HRV
rhinovirus
Respiratory system
Chile
Respiratory Tract Infections
Severe infantile respiratory infection
hMPV
human metapneumovirus
Immunoassay
Respiratory tract infections
biology
Reverse Transcriptase Polymerase Chain Reaction
musculoskeletal
neural
and ocular physiology
Respiratory disease
virus diseases
Viral Load
NPA
nasopharyngeal aspirates
Infectious Diseases
ALTRI
Treatment Outcome
Coinfection
Female
Viral load
medicine.medical_specialty
Genotype
RT-PCR
reverse transcription-polymerase chain reaction
macromolecular substances
Respiratory Syncytial Virus Infections
Real-Time Polymerase Chain Reaction
Article
Human metapneumovirus
Virology
Internal medicine
Severity of illness
Humans
IFA
indirect immunofluorescence assay
Picornaviridae Infections
business.industry
Infant
biology.organism_classification
medicine.disease
nervous system
Respiratory Syncytial Virus
Human
Immunology
RSV
respiratory syncytial virus
business
Zdroj: Journal of Clinical Virology
ISSN: 1873-5967
1386-6532
Popis: Highlights • Bronchiolitis by respiratory syncytial virus is more severe than by rhinovirus. • NA1 genotype had major hospitalization rate, severe disease and higher viral load. • Co-infection by RSV and HRV does not increase the severity of respiratory illness.
Background Respiratory syncytial virus (RSV) and rhinovirus (HRV) are the main cause of acute lower respiratory tract infections (ALRTIs) in infants. Viral and host-related risk factors for severe disease have also not been clearly established. Objective To assess whether certain viral features of RSV and, or HRV are associated with severe ALRTI. Study design RSV and HRV were studied in nasopharyngeal samples of infants by immunofluorescence, Luminex® and/or real-time RT-PCR assays. Quantitation and genotyping of RSV and HRV by PCR were done. Results Of 124 virus positive specimens, 74 (59.7%) had RSV; 22 (17.7%) HRV and 28 (22.6%) RSV-HRV co-infection. Hospitalization was required in 57/74 RSV infants (77.0%); in 10/22 HRV cases (45.5%) (p = 0.006) and in 15/28 co-infected by both viruses (53.6%) (p = 0.003). Severe cases were 33/74 (44.6%) RSV infections, 2/22 HRV cases (9.1%), (p
Databáze: OpenAIRE
Externí odkaz: