The cut-off effect of n-alcohols in lipid rafts: A lipid-dependent phenomenon
| Autor: | Patricio A. Zapata-Morin, Francisco J. Sierra-Valdez, J. C. Ruiz-Suárez |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
010304 chemical physics Chemistry N alcohols High variability Biological activity Molecular Dynamics Simulation 01 natural sciences Computer Graphics and Computer-Aided Design Lipids Action sites 03 medical and health sciences Molecular dynamics Membrane Microdomains Membrane protein Alcohols 0103 physical sciences Materials Chemistry Biophysics Physical and Theoretical Chemistry Receptor Lipid raft Spectroscopy 030304 developmental biology Anesthetics |
| Zdroj: | Journal of molecular graphicsmodelling. 101 |
| ISSN: | 1873-4243 |
| Popis: | n-Aliphatic alcohols act as anesthetics only up to a certain chain length, beyond which its biological activity disappears. This is known as the 'cut-off' phenomenon. Although the most accepted explanation is based on action sites in membrane proteins, it is not well understood why alcohols alter their functions. The structural dependence of these protein receptors to lipid domains known as 'lipid rafts', suggests a new approach to tackle the puzzling phenomenon. In this work, by performing molecular dynamic simulations (MDS) to explore the lipid role, we provide relevant molecular details about the membrane-alcohol interaction at the cut-off point regime. Since the high variability of the cut-off points found on protein receptors in neurons may be a consequence of differences in the lipid composition surrounding such proteins, our results could have a clear-cut importance. |
| Databáze: | OpenAIRE |
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