The cerebellar cognitive profile
| Autor: | Marco Molinari, Francesca R. Chiricozzi, Silvia Clausi, Michela Lupo, Maria Leggio, Anna Maria Tedesco |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Cerebellum Ataxia Neuropsychological Tests Deep cerebellar nuclei Procedural memory Lesion Cognition procedural learning ataxia sequence processing cognition cerebellum Cerebellar Diseases medicine Humans Aged Retrospective Studies Neurologic Examination Brain Mapping Middle Aged medicine.disease medicine.anatomical_structure nervous system Cerebellar cognitive affective syndrome Female Neurology (clinical) medicine.symptom Large group Psychology Neuroscience |
| Zdroj: | Brain : a journal of neurology. 134(Pt 12) |
| ISSN: | 1460-2156 |
| Popis: | The cerebellar role in non-motor functions is supported by the clinical finding that lesions confined to cerebellum produce the cerebellar cognitive affective syndrome. Nevertheless, there is no consensus regarding the overall cerebellar contribution to cognition. Among other reasons, this deficiency might be attributed to the small sample sizes and narrow breadths of existing studies on lesions in cerebellar patients, which have focused primarily on a single cognitive domain. The aim of this study was to examine the expression of cerebellar cognitive affective syndrome with regard to lesion topography in a large group of subjects with cerebellar damage. We retrospectively analysed charts from patients in the Ataxia Lab of Santa Lucia Foundation between 1997 and 2007. Of 223 charts, 156 were included in the study, focusing on the importance of the cerebellum in cognition and the relevance of lesion topography in defining the cognitive domains that have been affected. Vascular topography and the involvement of deep cerebellar nuclei were the chief factors that determined the cognitive profile. Of the various cognitive domains, the ability to sequence was the most adversely affected in nearly all subjects, supporting the hypothesis that sequencing is a basic cerebellar operation. |
| Databáze: | OpenAIRE |
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