Biocompatible and self-recoverable succinoglycan dialdehyde-crosslinked alginate hydrogels for pH-controlled drug delivery
| Autor: | Seonmok Kim, Seunho Jung |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Polymers and Plastics
Alginates Antimetabolites 02 engineering and technology 010402 general chemistry Polysaccharide 01 natural sciences Catalysis Drug Delivery Systems Materials Chemistry Humans Cytotoxicity Cell Proliferation chemistry.chemical_classification Sinorhizobium meliloti biology Chemistry Organic Chemistry Polysaccharides Bacterial Hydrogels Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology Biocompatible material biology.organism_classification 0104 chemical sciences HEK293 Cells Chemical engineering Drug delivery Self-healing hydrogels Degradation (geology) Fluorouracil 0210 nano-technology Rheology |
| Zdroj: | Carbohydrate polymers. 250 |
| ISSN: | 1879-1344 |
| Popis: | We fabricated polysaccharide-based hydrogels, which are biocompatible, self-recoverable and pH-sensitive. Succinoglycan dialdehyde (SGDA) was first synthesized from bacterial succinoglycan directly isolated from Sinorhizobium meliloti and then hydrazine-functionalized alginate (HZ-Alg) was prepared to form SGDA-crosslinked alginate hydrogels (SGDA/HZ-Alg) without any catalyst. Due to structural characteristics of SGDA, SGDA/HZ-Alg were effectively obtained in a short time even at low concentrations (0.94-1.57 wt%) where they exhibited self-recoverable and tunable rheological properties corresponding to efficiency of recovery from 93.2%-97.9%. Moreover, SGDA/HZ-Alg showed the pH-responsive degradation as well as pH-controlled release behavior for 5-fluorouracil. 5-Fluorouracil was released approximately 98 % at pH 2.0 within 12 h, but not completely released even after 24 h at pH 7.4. The WST-8 assay results also demonstrated that SGDA/HZ-Alg did not show any cytotoxicity against HEK-293 cells. Since the suggested hydrogels are biocompatible, rheologically self-recoverable and tunable, and pH-controllable, they would be potential biomaterials for the hydrogel-based drug delivery systems. |
| Databáze: | OpenAIRE |
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