Comparison of transplanted islets in patients with functioning versus nonfunctioning allografts
| Autor: | C. J. Swanson, Neil H. White, Daniel C. Brennan, T. Mohanakumar, Karen Flavin, P. E. Lacy, D. W. Scharp, B. J. Olack |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
endocrine system
medicine.medical_specialty Time Factors endocrine system diseases medicine.medical_treatment Urology Islets of Langerhans Transplantation Human leukocyte antigen Cell Separation Cryopreservation chemistry.chemical_compound Islets of Langerhans medicine Humans Transplantation Homologous Diabetic Nephropathies Treatment Failure Kidney transplantation Retrospective Studies Transplantation Kidney geography geography.geographical_feature_category C-Peptide business.industry C-peptide Immunosuppression Islet medicine.disease Kidney Transplantation surgical procedures operative medicine.anatomical_structure Diabetes Mellitus Type 1 Treatment Outcome chemistry Immunology Kidney Failure Chronic Surgery Drug Therapy Combination business Immunosuppressive Agents |
| Zdroj: | Transplantation proceedings. 29(4) |
| ISSN: | 0041-1345 |
| Popis: | INCE 1985,27 transplants have occurred at Washington University School of Medicine (WUMS) in St. Louis and 4 transplants in conjunction with the University of Western Ontario, London, Ontario. The majority of suc- cessful transplants have occurred since 1989 when we entered into the era of better immunosuppression, early intensive insulin therapy, purer preparations, immunoalter- ation by 24°C culture, and cryopreservation resulting in larger transplanted islet preparations. The two groups of patients most extensively followed at WUMS were patients with established kidney grafts followed by islet transplant (EKI, n = 8) and those receiving simultaneously trans- planted kidney and islet transplant (SKI, n = 9). Several controversies concerning islet transplantation still exist. For example, should islet transplantation occur simultaneous with or following renal transplant? Does cryopreservation and/or islet culture make a difference in islet function? What is the role of human leukocyte antigen (HLA) matching? Does islet mass improve or hamper long-term islet function? Presented here are the results of a retrospec- tive study addressing these questions in regard to our EKI and SKI patients. |
| Databáze: | OpenAIRE |
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