Increased glutamate levels in the vitreous of patients with retinal detachment

Autor: Hans M.H. van Eijk, Fred Hendrikse, Nicolaas E. P. Deutz, Albert T.A. Liem, Suzanne C. Dieudonné, Aize Kijlstra, Alfons G.H. Kessels, Roselie M.H. Diederen, Ellen C. La Heij
Přispěvatelé: Ophthalmology, Oogheelkunde, Algemene Heelkunde, MUMC+: KIO Kemta (9), RS: NUTRIM School of Nutrition and Translational Research in Metabolism
Jazyk: angličtina
Rok vydání: 2006
Předmět:
Male
gamma-Aminobutyric Acid/analysis
Vitreous Body/chemistry
genetic structures
Taurine
Visual Acuity/physiology
medicine.medical_treatment
Excitotoxicity
Visual Acuity
degeneration
Vitrectomy
medicine.disease_cause
Retinal Detachment/metabolism
chemistry.chemical_compound
invivo
gamma-Aminobutyric Acid
gaba
Neurotransmitter Agents
Retinal detachment
Anatomy
Diabetic retinopathy
Middle Aged
Sensory Systems
amino-acid signatures
Glycine/analysis
Amino acid neurotransmitter
Vitrectomy/methods
Female
Epiretinal membrane
Wageningen Livestock Research
Aspartic Acid/analysis
medicine.medical_specialty
GABA Agents
rat retina
Glycine
Glutamic Acid
ischemia
growth-factor
in-vitro
GABA Agents/analysis
Cellular and Molecular Neuroscience
Ophthalmology
medicine
Humans
Retrospective Studies
Aspartic Acid
Retinal Detachment
Retinal
Glutamic acid
ganglion-cells
medicine.disease
eye diseases
Vitreous Body
glaucoma
chemistry
Taurine/analysis
Glutamic Acid/analysis
sense organs
Neurotransmitter Agents/analysis
Zdroj: Experimental Eye Research 83 (2006) 1
Experimental eye research, 83(1), 45-50. Academic Press Inc.
Experimental Eye Research, 83(1), 45-50
Experimental Eye Research, 83(1), 45-50. Elsevier Science
ISSN: 1096-0007
0014-4835
Popis: Experimental models have implicated glutamate in the irreversible damage to retinal cells following retinal detachment. In this retrospective study we investigated a possible role for glutamate and other amino acid neurotransmitters during clinical rhegmatogenous retinal detachment (RRD). Undiluted vitreous samples were obtained from 176 patients undergoing pars plana vitrectomy. The study group consisted of 114 patients (114 eyes) with a rhegmatogenous retinal detachment. Controls included 52 eyes with an idiopathic macular hole or idiopathic epiretinal membrane and 10 eyes with a traction retinal detachment due to proliferative diabetic retinopathy. Vitreous concentrations of glutamate, gamma-aminobutyric acid (GABA), taurine, glycine, and aspartate were determined by high-pressure liquid chromatography (HPLC). Multivariate analysis was used to examine a possible association between amino acid neurotransmitter levels and several clinical variables including visual acuity. The mean vitreous concentration of glutamate in eyes with a rhegmatogenous retinal detachment (16.6 +/- 5.6 microM) was significantly higher as compared to the controls (13.1 +/- 5.2 microM) (P = 0.001). Taurine levels were also increased in RRD, whereas no significant difference could be observed in glycine, aspartate and GABA levels when comparing RRD with controls. A correlation was found between increased vitreous glutamate and a lower pre-operative visual acuity. No association was, however, observed between post-operative visual acuity and the level of any of the five amino acid neurotransmitters. RRD was associated with a significantly increased vitreous glutamate concentration. Using visual acuity as a functional parameter in this study, we could not demonstrate a correlation between vitreous glutamate, or any of the other tested amino acid neurotransmitters and visual outcome.
Databáze: OpenAIRE
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