Venom gland transcriptomics for identifying, cataloging, and characterizing venom proteins in snakes
| Autor: | Ryan J.R. McCleary, Rajeev Kungur Brahma, Robin Doley, R. Manjunatha Kini |
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| Přispěvatelé: | Brahma, Rajeev Kungur, McCleary, Ryan JR, Kini, R Manjunatha, Doley, Robin |
| Rok vydání: | 2014 |
| Předmět: |
venom gland
Gene Expression Profiling Proteins Venom Snakes Computational biology Venom gland Quantitative variation Biology Toxicology Bioinformatics complex mixtures Transcriptome venomics Evolution Molecular venom complexity Species Specificity Snake venom Animals venom protein cataloging Envenomation transcriptome venom protein evolution snake venom Snake Venoms |
| Zdroj: | Toxicon : official journal of the International Society on Toxinology. 93 |
| ISSN: | 1879-3150 |
| Popis: | Snake venoms are cocktails of protein toxins that play important roles in capture and digestion of prey. Significant qualitative and quantitative variation in snake venom composition has been observed among and within species. Understanding these variations in protein components is instrumental in interpreting clinical symptoms during human envenomation and in searching for novel venom proteins with potential therapeutic applications. In the last decade, transcriptomic analyses of venom glands have helped in understanding the composition of various snake venoms in great detail. Here we review transcriptomic analysis as a powerful tool for understanding venom profile, variation and evolution. Refereed/Peer-reviewed |
| Databáze: | OpenAIRE |
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