Bifurcation of Cell Migratory and Proliferative Signaling by the Adaptor Protein Shc
| Autor: | Linda Yeh, David A. Cheresh, Lila R. Collins, William Ricketts |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Shc
cell migration medicine.medical_treatment SH2 domain environment and public health chemistry.chemical_compound 0302 clinical medicine Cell Movement Tumor Cells Cultured Neoplasm Metastasis Phosphorylation mitogenesis Growth Substances 0303 health sciences biology Signal transducing adaptor protein Cell migration Cell biology PTB 030220 oncology & carcinogenesis COS Cells Original Article biological phenomena cell phenomena and immunity Signal transduction Cell Division hormones hormone substitutes and hormone antagonists Signal Transduction DNA Replication Src Homology 2 Domain-Containing Transforming Protein 1 Integrin Mitosis Transfection Cell Line 03 medical and health sciences medicine Animals Humans Adaptor Proteins Signal Transducing 030304 developmental biology Growth factor Proteins Tyrosine phosphorylation Cell Biology SH2 Adaptor Proteins Vesicular Transport Shc Signaling Adaptor Proteins chemistry biology.protein Tyrosine Phosphotyrosine-binding domain |
| Zdroj: | The Journal of Cell Biology |
| ISSN: | 1540-8140 0021-9525 |
| DOI: | 10.1083/jcb.147.7.1561 |
| Popis: | Cytokines and extracellular matrix proteins initiate signaling cascades that regulate cell migration and proliferation. Evidence is provided that the adaptor protein Shc can differentially regulate these processes. Specifically, under growth factor–limiting conditions, Shc stimulates haptotactic cell migration without affecting anchorage-dependent proliferation. However, when growth factors are present, Shc no longer influences cell migration; rather, Shc is crucial for DNA synthesis. Mutational analysis of Shc demonstrates that, while tyrosine phosphorylation is required for both DNA synthesis and cell migration, the switch in Shc signaling is associated with differential use of Shc's phosphotyrosine interacting domains; the PTB domain regulates haptotaxis, while the SH2 domain is selectively required for proliferation. |
| Databáze: | OpenAIRE |
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