ALL relapse with multiple cranial nerve palsies and toxic leukoencephalopathy: treatment failure with treatment toxicity
Autor: | Jaslovleen Kaur, GR Singh, Birinder S Paul, Gagandeep Singh |
---|---|
Rok vydání: | 2018 |
Předmět: |
Adult
musculoskeletal diseases 0301 basic medicine medicine.medical_specialty Images In… medicine.medical_treatment Central nervous system Gastroenterology Treatment failure 03 medical and health sciences 0302 clinical medicine Leukoencephalopathies Internal medicine medicine Humans Treatment Failure Chemotherapy business.industry Cranial nerves Neurotoxicity General Medicine Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Cranial Nerve Diseases Toxic leukoencephalopathy Methotrexate 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Toxicity Female Neoplasm Recurrence Local business Immunosuppressive Agents medicine.drug |
Zdroj: | BMJ Case Rep |
ISSN: | 1757-790X |
DOI: | 10.1136/bcr-2018-224987 |
Popis: | Acute lymphoblastic leukaemia (ALL) is one of the most common malignancies of childhood. ALL is treated with high doses of methotrexate (MTX) to prevent central nervous system (CNS) and haematological relapses. MTX is administered intravenously and via intrathecal route.1 MTX can cause neurotoxicity by disrupting CNS folate homeostasis or by direct neuronal damage. MTX-induced acute toxic leukoencephalopathy can result in acute neurological deficit, seizures or encephalopathy.2 We report a 27-year-old diagnosed case of ALL who presented with neurological symptoms 2 years after she was started with intensive and maintenance phase of chemotherapy. She took multiple cycles (24) of intrathecal MTX in her intensive phase and … |
Databáze: | OpenAIRE |
Externí odkaz: |