Maternal Smoking during Pregnancy and Fetal Organ Growth: A Magnetic Resonance Imaging Study
| Autor: | Nia W. Jones, Zdenka Pausova, Neil Roberts, Alexander J. J. Parker, Ruta Deshpande, Lucy H. Coyne, Kirsty Allcock, George Bugg, Penny A. Gowland, Tomáš Paus, Nick Raine-Fenning, Devasuda Anblagan, Rosanne Aleong, Carolyn Costigan |
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| Rok vydání: | 2013 |
| Předmět: |
Medical Physics
Placenta lcsh:Medicine Kidney Pediatrics Diagnostic Radiology Pregnancy Birth Weight Lung volumes Growth Retardation lcsh:Science Multidisciplinary medicine.diagnostic_test Obstetrics Physics Smoking Obstetrics and Gynecology Brain Gestational age Organ Size Magnetic Resonance Imaging medicine.anatomical_structure Maternal Exposure embryonic structures Maternal Smoking Medicine Female Fetal Organ Maturity Public Health Radiology Research Article Adult medicine.medical_specialty Tobacco Control Adolescent Clinical Research Design Birth weight Gestational Age PEMCS Young Adult medicine Humans Fetal Organ Fetus business.industry lcsh:R Magnetic resonance imaging medicine.disease Fetal Assessment Case-Control Studies lcsh:Q business |
| Zdroj: | Anblagan, D, Jones, N W, Costigan, C, Parker, A J J, Allcock, K, Aleong, R, Coyne, L H, Deshpande, R, Raine-Fenning, N, Bugg, G, Roberts, N, Pausova, Z, Paus, T & Gowland, P A 2013, ' Maternal Smoking during Pregnancy and Fetal Organ Growth : A Magnetic Resonance Imaging Study ', PLoS ONE, vol. 8, no. 7, e67223 . https://doi.org/10.1371/journal.pone.0067223 PLoS ONE PLoS ONE, Vol 8, Iss 7, p e67223 (2013) |
| ISSN: | 1932-6203 |
| Popis: | Objective: To study whether maternal cigarette smoking during pregnancy is associated with alterations in the growth of fetal lungs, kidneys, liver, brain, and placenta.Design: A case-control study, with operators performing the image analysis blinded.Setting: Study performed on a research-dedicated magnetic resonance imaging (MRI) scanner (1.5 T) with participants recruited from a large teaching hospital in the United Kingdom.Participants: A total of 26 pregnant women (13 current smokers, 13 non smokers) were recruited; 18 women (10 current smokers, 8 nonsmokers) returned for the second scan later in their pregnancy.Methods: Each fetus was scanned with MRI at 22–27 weeks and 33–38 weeks gestational age (GA).Main outcome measures: Images obtained with MRI were used to measure volumes of the fetal brain, kidneys, lungs, liver and overall fetal size, as well as placental volumes.Results: Exposed fetuses showed lower brain volumes, kidney volumes, and total fetal volumes, with this effect being greater at visit 2 than at visit 1 for brain and kidney volumes, and greater at visit 1 than at visit 2 for total fetal volume. Exposed fetuses also demonstrated lower lung volume and placental volume, and this effect was similar at both visits. No difference was found between the exposed and nonexposed fetuses with regards to liver volume.Conclusion: Magnetic resonance imaging has been used to show that maternal smoking is associated with reduced growth of fetal brain, lung and kidney; this effect persists even when the volumes are corrected for maternal education, gestational age, and fetal sex. As expected, the fetuses exposed to maternal smoking are smaller in size. Similarly, placental volumes are smaller in smoking versus nonsmoking pregnant women. |
| Databáze: | OpenAIRE |
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