Mu and delta opioid receptors oppositely regulate motor impulsivity in the signaled nose poke task
| Autor: | Mary C. Olmstead, Abdel-Mouttalib Ouagazzal, Brigitte L. Kieffer |
|---|---|
| Přispěvatelé: | Department of Psychology, Queen's University [Kingston, Canada], Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Louis Pasteur - Strasbourg I, Peney, Maité, Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2008 |
| Předmět: |
medicine.drug_class
Mental Health/Neuropsychiatric Disorders Receptors Opioid mu lcsh:Medicine Context (language use) Biology Impulsivity 03 medical and health sciences Mice 0302 clinical medicine Reward Opioid receptor Dopamine Receptors Opioid delta Conditioning Psychological [SDV.BBM] Life Sciences [q-bio]/Biochemistry Molecular Biology medicine Animals [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology lcsh:Science 030304 developmental biology Endogenous opioid Mice Knockout 0303 health sciences Multidisciplinary Neuroscience/Behavioral Neuroscience Behavior Animal lcsh:R Associative learning Neuroscience/Experimental Psychology Disruptive Impulse Control and Conduct Disorders Mice Inbred C57BL Opioid Mental Health/Substance Abuse Disinhibition Anesthesia lcsh:Q medicine.symptom Cues Neuroscience 030217 neurology & neurosurgery medicine.drug Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 4, Iss 2, p e4410 (2009) PLoS ONE, Public Library of Science, 2009, 4 (2), pp.e4410. ⟨10.1371/journal.pone.0004410⟩ PLoS ONE, 2009, 4 (2), pp.e4410. ⟨10.1371/journal.pone.0004410⟩ |
| ISSN: | 1932-6203 |
| Popis: | International audience; Impulsivity is a primary feature of many psychiatric disorders, most notably attention deficit hyperactivity disorder and drug addiction. Impulsivity includes a number of processes such as the inability to delay gratification, the inability to withhold a motor response, or acting before all of the relevant information is available. These processes are mediated by neural systems that include dopamine, serotonin, norepinephrine, glutamate and cannabinoids. We examine, for the first time, the role of opioid systems in impulsivity by testing whether inactivation of the mu- (Oprm1) or delta- (Oprd1) opioid receptor gene alters motor impulsivity in mice. Wild-type and knockout mice were examined on either a pure C57BL6/J (BL6) or a hybrid 50% C57Bl/6J-50% 129Sv/pas (HYB) background. Mice were trained to respond for sucrose in a signaled nose poke task that provides independent measures of associative learning (responses to the reward-paired cue) and motor impulsivity (premature responses). Oprm1 knockout mice displayed a remarkable decrease in motor impulsivity. This was observed on the two genetic backgrounds and did not result from impaired associative learning, as responses to the cue signaling reward did not differ across genotypes. Furthermore, mutant mice were insensitive to the effects of ethanol, which increased disinhibition and decreased conditioned responding in wild-type mice. In sharp contrast, mice lacking the Oprd1 gene were more impulsive than controls. Again, mutant animals showed no deficit in associative learning. Ethanol completely disrupted performance in these animals. Together, our results suggest that mu-opioid receptors enhance, whereas delta-opioid receptors inhibit, motor impulsivity. This reveals an unanticipated contribution of endogenous opioid receptor activity to disinhibition. In a broader context, these data suggest that alterations in mu- or delta-opioid receptor function may contribute to impulse control disorders. |
| Databáze: | OpenAIRE |
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