Insulin-Like Growth Factor, Inflammation, and MRI Markers of Alzheimer's Disease in Predominantly Middle-Aged Adults
| Autor: | Katharina Wittfeld, Mekala R. Raman, Sarah C. Conner, Asra Aslam, Alexander Teumer, Matthias Nauck, Norbert Hosten, Mohamad Habes, Charles DeCarli, Ramachandran S. Vasan, Alexa S. Beiser, Jayandra J. Himali, Sudha Seshadri, Hans J. Grabe, Claudia L. Satizabal |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Adult
Male Aging hippocampus Clinical Sciences metabolism [C-Reactive Protein] Neurodegenerative Alzheimer's Disease Article C-reactive protein insulin-like growth factor Alzheimer’s disease endophenotype Clinical Research Alzheimer Disease Acquired Cognitive Impairment Alzheimer's disease endophenotype cohort study 2.1 Biological and endogenous factors Humans ddc:610 Aetiology Insulin-Like Growth Factor I analysis [Insulin-Like Growth Factor I] Inflammation Neurology & Neurosurgery neuroimaging General Neuroscience diagnostic imaging [Inflammation] white matter hyperintensity Neurosciences Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) General Medicine Middle Aged Magnetic Resonance Imaging Brain Disorders Psychiatry and Mental health Clinical Psychology C-Reactive Protein Insulin-Like Growth Factor Binding Protein 3 Neurological Dementia Cognitive Sciences Female epidemiology Geriatrics and Gerontology diagnostic imaging [Alzheimer Disease] Biomarkers |
| Zdroj: | Journal of Alzheimer's disease 88(1), 311-322 (2022). doi:10.3233/JAD-220356 J Alzheimers Dis Journal of Alzheimer's disease : JAD, vol 88, iss 1 |
| Popis: | Background: Insulin-like growth factor 1 (IGF-1) signaling has been implicated in Alzheimer’s disease pathogenesis, and further evidence suggests inflammation can be a moderator of this association. However, most research to date has been conducted on older adults. Objective: To investigate the association of serum IGF-1 and IGF binding protein 3 (IGFBP-3) concentrations with MRI markers of Alzheimer’s disease in predominantly middle-aged adults, and further assess moderation by chronic inflammation. Methods: We included participants from the Framingham Heart Study (n = 1,852, mean age 46±8, 46% men) and the Study of Health in Pomerania (n = 674, mean age 50±13, 42% men) with available serum IGF-1, IFGBP-3, as well as brain MRI. IGF-1 and IFGBP-3 were related to MRI outcomes (i.e., total brain, cortical gray matter, white matter, white matter hyperintensities (WMH), and hippocampal volumes) using multivariable regression models adjusting for potential confounders. Subgroup analyses by C-reactive protein (CRP) concentrations were also performed. Cohort-specific summary statistics were meta-analyzed using random-effects models and corrected for multiple comparisons. Results: Meta-analysis results revealed that higher IGF-1 concentrations were associated with lower WMH (estimate [β] [95% CI], –0.05 [–0.09, –0.02], p = 0.006) and larger hippocampal volumes (0.07 [0.02, 0.12], p = 0.01), independent of vascular risk factors. These associations occurred predominantly in individuals with CRP concentrations |
| Databáze: | OpenAIRE |
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