Effects of the oral direct thrombin inhibitor ximelagatran on p-selectin expression and thrombin generation in atrial fibrillation
| Autor: | Mia Svensson, Michael Wolzt, Troy C. Sarich, Margaretha Grind, Stig L. Boström, Karin Wåhlander |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Benzylamines Ximelagatran P-selectin Glycine Hemorrhage Oral administration Physiology (medical) Internal medicine Atrial Fibrillation medicine Humans Platelet activation Aged Cell adhesion molecule business.industry Thrombin Atrial fibrillation Thrombosis Hematology Middle Aged medicine.disease Platelet Activation P-Selectin Endocrinology Direct thrombin inhibitor Case-Control Studies Azetidines Female Blood Coagulation Tests business circulatory and respiratory physiology Discovery and development of direct thrombin inhibitors medicine.drug |
| Zdroj: | Pathophysiology of haemostasis and thrombosis. 33(2) |
| ISSN: | 1424-8832 |
| Popis: | This study investigated the pharmacodynamic effects of the oral direct thrombin inhibitor ximelagatran on platelet activation and thrombin generation in patients with nonvalvular atrial fibrillation. Using an open, group-matched study design, the effects of ximelagatran (36 mg twice daily for 5 days) were studied in 12 patients with permanent nonvalvular atrial fibrillation and in 12 healthy controls. After ximelagatran for 5 days, elevated platelet P-selectin expression in atrial fibrillation patients was lowered to that during coumarin treatment or in controls but had no effect in control subjects. Using the endogenous thrombin potential as a marker, ximelagatran decreased and delayed thrombin generation in both groups. In conclusion, direct thrombin inhibition with ximelagatran reduced elevated platelet P-selectin expression and inhibited thrombin generation. |
| Databáze: | OpenAIRE |
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