The inhibition of sulphate incorporation in isolated adult chondrocytes by hyaluronic acid
| Autor: | Ole W. Wiebkin, Helen Muir |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Male
Biophysics Matrix (biology) Sulfur Radioisotopes Cetylpyridinium chloride Biochemistry Glycosaminoglycan chemistry.chemical_compound Biosynthesis Structural Biology Synovial Fluid Hyaluronic acid Genetics medicine Humans Protamines Hyaluronic Acid Molecular Biology Cells Cultured chemistry.chemical_classification Sulfates Cartilage Cell Biology Fibroblasts Enzyme medicine.anatomical_structure chemistry Depression Chemical Female Muramidase Chondroitin Macromolecule |
| Zdroj: | FEBS Letters. 37:42-46 |
| ISSN: | 0014-5793 |
| Popis: | Proteoglycans in the matrix of adult cartilage are metabolised quite rapidly [ 1,2], nevertheless adult cartilage has a limited capacity for repair. Embryonic cartilage on the other hand, is able to replace the proteoglycans of the matrix within a few days after they have been largely depleted by the action of enzymes [3,4], which suggests that the macromolecules in the environment exert some influence over the synthetic or secretory functions of chondrocytes. The possible influence of a variety of macromolecules on the biosynthesis of sulphated glycosaminoglycans has therefore been examined using suspensions of nondividing adult chondrocytes, obtained from pig laryngeal and articular cartilage. Cartilage contains small amounts of hyaluronic acid [5], low concentrations of which have important biological effects [6]. The effect of low concentrations of hyaluronic acid on the incorporation of 35SOiinto material precipitable by cetylpyridinium chloride (CPC) is reported here. |
| Databáze: | OpenAIRE |
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