The network sustaining action myoclonus: a MEG-EMG study in patients with EPM1
| Autor: | Elisa Visani, Silvana Franceschetti, Alice Granvillano, Ferruccio Panzica, Laura Canafoglia, Fabio Rotondi |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male Myoclonus Recruitment Neurophysiological medicine.medical_specialty Neurology Action myoclonus Clinical Neurology Cortico-muscular coherence macromolecular substances Isometric exercise 03 medical and health sciences Young Adult 0302 clinical medicine Unverricht-Lundborg Syndrome medicine Humans Neurochemistry Aged MEG medicine.diagnostic_test business.industry Electromyography Magnetoencephalography General Medicine Neurophysiology Middle Aged 030104 developmental biology Cortical network Case-Control Studies Female Neurology (clinical) medicine.symptom business Neuroscience 030217 neurology & neurosurgery Research Article |
| Zdroj: | BMC Neurology |
| ISSN: | 1471-2377 |
| Popis: | Background To explore the cortical network sustaining action myoclonus and to found markers of the resulting functional impairment, we evaluated the distribution of the cortico-muscular coherence (CMC) and the frequency of coherent cortical oscillations with magnetoencephalography (MEG). All patients had EPM1 (Unverricht-Lundborg) disease known to present with prominent and disabling movement-activated myoclonus. Methods Using autoregressive models, we evaluated CMC on MEG sensors grouped in regions of interests (ROIs) above the main cortical areas. The movement was a repeated sustained isometric extension of the right hand and right foot. We compared the data obtained in 10 EPM1 patients with those obtained in 10 age-matched controls. Results As expected, CMC in beta band was significantly higher in EPM1 patients compared to controls in the ROIs exploring the sensorimotor cortex, but, it was also significantly higher in adjacent ROIs ipsilateral and contralateral to the activated limb. Moreover, the beta-CMC peak occurred at frequencies significantly slower and more stable frequencies in EPM1 patients with respect to controls. The frequency of the beta-CMC peak inversely correlated with the severity of myoclonus. Conclusions the high and spatially extended beta-CMC peaking in a restricted range of low-beta frequencies in EPM1 patients, suggest that action myoclonus may result not only from an enhanced local synchronization but also from a specific oscillatory activity involving an expanded neuronal pool. The significant relationship between beta-CMC peak frequency and the severity of the motor impairment can represent a useful neurophysiological marker for the patients’ evaluation and follow-up. |
| Databáze: | OpenAIRE |
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