Bipolar Electrochemical Measurement of Enantiomeric Excess with Inherently Chiral Polymer Actuators
| Autor: | Gerardo Salinas, Roberto Cirilli, Giorgia Bonetti, Alexander Kuhn, Tiziana Benincori, Serena Arnaboldi |
|---|---|
| Přispěvatelé: | Institut Polytechnique de Bordeaux (Bordeaux INP), ERC Electra, European Project: 741251,ERC Advanced ELECTRA |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Environmental Engineering
Materials science 02 engineering and technology 010402 general chemistry Electrochemistry 01 natural sciences Article Industrial and Manufacturing Engineering Absolute Enantiodiscrimination Metrics & More Article Recommendations Electrochemical Actuators Bipolar Electrochemistry [CHIM]Chemical Sciences Electrochemical Actuators Enantiomeric excess chemistry.chemical_classification QD71-142 Polymer 021001 nanoscience & nanotechnology 0104 chemical sciences Chemical engineering chemistry Direct Enantiomeric Excess Determination Inherent Chirality 0210 nano-technology Actuator Analytical chemistry |
| Zdroj: | ACS Measurement Science Au, Vol 1, Iss 3, Pp 110-116 (2021) ACS Measurement Science Au ACS Measurement Science Au, 2021, 1 (3), pp.110-116. ⟨10.1021/acsmeasuresciau.1c00011⟩ |
| ISSN: | 2694-250X |
| DOI: | 10.1021/acsmeasuresciau.1c00011⟩ |
| Popis: | International audience; Straightforward enantioselective analytical methods are very important for drug safety, considering that in certain cases one of the two enantiomers of a chiral molecule might be harmful for humans. In this work, we propose a simple system for the direct and easy read-out of the enantiomeric excess of 3,4-dihydroxyphenylalanine (DOPA) as a model analyte. A conducting oligomer, i.e. oligo-(3,3′-dibenzothiophene), bearing inherently chiral features, is electrogenerated on a polypyrrole film. The resulting freestanding hybrid material is used as a wireless enantioselective actuator in a bipolar electrochemical cell. Combining in a single setup two individual actuators with opposite chiral features allows a direct visual read-out of enantiomeric excess, as the bending amplitude of each of the two actuators is directly correlated with the concentration of the corresponding stereoisomer of the analyte. Optimization of the experimental parameters results in efficient bending, giving access to the percentage values of the enantiomeric excess in mixtures containing different ratios of the antipodes, thus opening the way to potential applications for chiral in situ analysis. |
| Databáze: | OpenAIRE |
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