Evidence of the Presence of Thyroid Hormones in Achatina fulica Snails
| Autor: | Vinícius Menezes Tunholi-Alves, Alba C.M. Silva, Jairo Pinheiro, Denise P. Carvalho, Rosane Nora Castro, Danilo Lustrino, Victor Menezes Tunholi, Iracema G. Araujo, Michelle P. Marassi |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Thyroid hormones Sodium medicine.medical_treatment Snails chemistry.chemical_element Sodium/iodine symport Thyroglobulin 03 medical and health sciences 0302 clinical medicine In vivo Hemolymph Internal medicine medicine Animals lcsh:Science Chromatography High Pressure Liquid Multidisciplinary biology Biological Transport Radioimmunoassay Metabolism biology.organism_classification Sodium Chloride Symporters Thyroxine 030104 developmental biology Endocrinology Achatina chemistry Achatina fulica Symporter activity lcsh:Q 030217 neurology & neurosurgery |
| Zdroj: | Anais da Academia Brasileira de Ciências v.89 n.3 suppl.0 2017 Anais da Academia Brasileira de Ciências Academia Brasileira de Ciências (ABC) instacron:ABC Anais da Academia Brasileira de Ciências, Iss 0 Anais da Academia Brasileira de Ciências, Volume: 89, Issue: 3 Supplement, Pages: 2181-2188, Published: 24 JUL 2017 |
| ISSN: | 1678-2690 0001-3765 |
| DOI: | 10.1590/0001-3765201720160698 |
| Popis: | The objective of this study was to identify thyroid hormones and to examine their putative site of synthesis in Achatina fulica snails. For this purpose, radioimmunoassays were performed for T3 and T4 before and after long starvation with or without hemolymph deproteinization. Sodium/iodide symporter activity in vivo was analyzed through 125I administration with and without KClO4 pretreatment. Only T4 was detected, and its concentration decreased due to starvation or deproteinization. However, high-performance liquid chromatography analysis also showed the presence of T2 and T3 apart from T4, but rT3 was not detected in the A. fulica hemolymph. The sodium/iodide symporter activity was greater in cerebral ganglia than digestive gland, but KClO4 treatment did not inhibit iodide uptake in any of the tissues analyzed. Altogether, our data confirm for the first time the presence of thyroid hormones in A. fulica snails and suggest their participation in the metabolism control in this species, although the putative site of hormone biosynthesis remains to be elucidated. |
| Databáze: | OpenAIRE |
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