Compact Cell Imaging Device (CoCID) provides insights into the cellular origins of viral infections
| Autor: | Kenneth Fahy, Tony McEnroe, Pablo Gastaminza, Axel Ekman, Nicola F. Fletcher, Ralf Bartenschlager, Venera Weinhardt, Maija Vihinen-Ranta, Dunja Skoko, Dimitri Scholz, Eva Pereiro |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
2019-20 coronavirus outbreak
Coronavirus disease 2019 (COVID-19) virukset Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Cell tutkimuslaitteet Biology mikroskopia water window infektiot 03 medical and health sciences 0302 clinical medicine herpesvirus soft x-ray microscopy medicine hepatiitti C -virus Electrical and Electronic Engineering herpesvirukset 030304 developmental biology 0303 health sciences hepatiitti E -virus SARS-CoV-2 röntgensäteily SARS-CoV-2-virus Hepatitis C medicine.disease Hepatitis E Virology Atomic and Molecular Physics and Optics 3. Good health Electronic Optical and Magnetic Materials medicine.anatomical_structure kuvantaminen fotoniikka 030220 oncology & carcinogenesis cell structure imaging hepatiittivirukset Soft x-ray microscopy hepatitis E hepatitis C solubiologia |
| Zdroj: | Journal of Physics: Photonics |
| Popis: | The overall CoCID concept is centred on providing virologists with a next-generation imaging device, which, through increased penetration and depth of focus, as well as through high natural contrast and sensitivity to organelle density (including virus-related organelles), will produce higher-fidelity ultrastructural images of whole intact cells. These insights will, in turn, help increase our understanding of the links between the structural reorganisation of cells and the mechanisms of viral entry, replication, assembly, and egress in cells. CoCID will provide this valuable imaging capability in the form of a compact lab-scale device that will greatly improve the accessibility of soft X-ray microscopy for the virologists' consortium within the CoCID project as well as the broader disease research community worldwide. |
| Databáze: | OpenAIRE |
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