A Novel Conductive and Micropatterned PEG-Based Hydrogel Enabling the Topographical and Electrical Stimulation of Myoblasts
| Autor: | Junggeon Park, Jongbaeg Kim, Wondo Kim, Jae Young Lee, Won Gun Koh, Hye Yeon Gong |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Materials science
Polymers Biocompatible Materials Stimulation macromolecular substances 02 engineering and technology Muscle Development 010402 general chemistry 01 natural sciences Cell Line Polyethylene Glycols Myoblasts Mice chemistry.chemical_compound PEDOT:PSS Elastic Modulus PEG ratio Animals Myocyte General Materials Science Electrical conductor technology industry and agriculture Cell Differentiation Hydrogels Bridged Bicyclo Compounds Heterocyclic musculoskeletal system 021001 nanoscience & nanotechnology Electric Stimulation 0104 chemical sciences chemistry 0210 nano-technology tissues C2C12 Ethylene glycol Biomedical engineering |
| Zdroj: | ACS Applied Materials & Interfaces. 11:47695-47706 |
| ISSN: | 1944-8252 1944-8244 |
| DOI: | 10.1021/acsami.9b16005 |
| Popis: | In this study, we designed a cell-adhesive poly(ethylene glycol) (PEG)-based hydrogel that simultaneously provides topographical and electrical stimuli to C2C12 myoblasts. Specifically, PEG hydrogels with microgroove structures of 3 μm ridges and 3 μm grooves were prepared by micromolding; in situ polymerization of poly(3,4-ethylenedioxythiophene) (PEDOT) was then performed within the micropatterned PEG hydrogels to create a microgrooved conductive hydrogel (CH/P). The CH/P had clear replica patterns of the silicone mold and a conductivity of 2.49 × 10 |
| Databáze: | OpenAIRE |
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