Lack of Cellular Inflammation in a Non-human Primate Model of Radiation Nephropathy
| Autor: | Eric P. Cohen, Ann M. Farese, Maureen A. Kane, George A. Parker, Thomas J. MacVittie |
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| Rok vydání: | 2020 |
| Předmět: |
Radiation Nephropathy
Epidemiology Health Toxicology and Mutagenesis Inflammation Article 030218 nuclear medicine & medical imaging End Stage Liver Disease 03 medical and health sciences 0302 clinical medicine medicine Kidney injury Animals Radiology Nuclear Medicine and imaging Acute radiation exposure Non human primate business.industry Radiation Exposure Macaca mulatta Disease Models Animal Radiation Injuries Experimental Acute Radiation Syndrome 030220 oncology & carcinogenesis Cancer research medicine.symptom business |
| Zdroj: | Health Phys |
| ISSN: | 1538-5159 |
| Popis: | Inflammation is commonly cited as a mechanism of delayed effects of acute radiation exposure (DEARE). Confirmation of its presence could provide significant insight to targeted use of treatments or mitigators of DEARE. We sought to quantify the presence of cellular inflammation in kidneys of non-human primates that developed acute and chronic kidney injury after a partial body irradiation exposure. We show herein that cellular inflammation is not found as a component of either acute or chronic kidney injury. Other mechanistic pathways of injury must be sought. |
| Databáze: | OpenAIRE |
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