Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction
| Autor: | Keigan M. Park, William J. Bowers |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Cell Survival
Context (language use) Biology Article Ion Channels Mice Alzheimer Disease medicine Animals Homeostasis Humans Receptor Neuroinflammation Neurons Neuronal Plasticity Microglia Tumor Necrosis Factor-alpha Brain Parkinson Disease Cell Biology Cell biology Ion homeostasis medicine.anatomical_structure Synaptic plasticity Immunology Tumor necrosis factor alpha Signal transduction Signal Transduction |
| Zdroj: | Cellular Signalling. 22:977-983 |
| ISSN: | 0898-6568 |
| DOI: | 10.1016/j.cellsig.2010.01.010 |
| Popis: | Tumor necrosis factor-alpha (TNF-alpha) is a potent pro-inflammatory molecule, which upon engagement with its cognate receptors on target cells, triggers downstream signaling cascades that control a number of cellular processes related to cell viability, gene expression, ion homeostasis, and synaptic integrity. In the central nervous system (CNS), TNF-alpha is produced by brain-resident astrocytes, microglia, and neurons in response to numerous intrinsic and extrinsic stimuli. This review will summarize the key events that lead to TNF-alpha elaboration in the CNS, and the effects that these inflammatory signals impart on neuronal signaling in the context of homeostasis and neuropathology. |
| Databáze: | OpenAIRE |
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