Isorhamnetin: A review of pharmacological effects
| Autor: | Shuang Zhou, Zhong-Lin Zhang, Su-Juan Wang, Ying-Yun Guan, Gang Gong, Hong Zhang, Xin Luan, Khalid Rahman |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
MAPK/ERK pathway RM RM1-950 Pharmacology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Hippophae Animals Humans Effect Medicine Isorhamnetin Protein kinase B PI3K/AKT/mTOR pathway Flavonoids Plants Medicinal biology Plant Extracts business.industry Mechanism (biology) Ginkgo biloba General Medicine biology.organism_classification Plant Leaves 030104 developmental biology Gene Expression Regulation Mechanism of action chemistry Fruit 030220 oncology & carcinogenesis Quercetin Mechanism Therapy Therapeutics. Pharmacology medicine.symptom Signal transduction business Signal Transduction |
| Zdroj: | Biomedicine & Pharmacotherapy, Vol 128, Iss, Pp 110301-(2020) |
| ISSN: | 0753-3322 |
| Popis: | Isorhamnetin is one of the most important active ingredients in the fruits of Hippophae rhamnoides L. and the leaves of Ginkgo biloba L., which possesses extensive pharmacological activities. At present, there have been numerous investigations on isorhamnetin, which has the effects of cardiovascular and cerebrovascular protection, anti-tumor, anti-inflammatory, anti-oxidation, organ protection, prevention of obesity, etc. The related mechanisms involve the regulation of PI3K/AKT/PKB, NF-κB, MAPK and other signaling pathways as well as the expression of related cytokines and kinases. Isorhamnetin has a high value of development and application. However, the investigations on its mechanism of action are limited and lack of detailed scientific validation. The manuscript reviewed the pharmacological effects of isorhamnetin and related mechanisms of action for the development of its medicinal properties further. |
| Databáze: | OpenAIRE |
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