The role of sex genotype in paediatric CNS tumour incidence and survival

Autor: Melpo Kapetanstrataki, Susan Picton, Paul Chumas, Edward Goacher, Wai Cheong Soon, Josie Hayes, Ryan K. Mathew, Sandeep Solanki
Rok vydání: 2021
Předmět:
Zdroj: Child's Nervous System
ISSN: 1433-0350
0256-7040
DOI: 10.1007/s00381-021-05165-0
Popis: Purpose Evidence exists, in CNS germinomas and medulloblastomas (MB), that patient sex significantly influences incidence and outcome. The role of sex genotype in other paediatric CNS tumours remains unclear. This study sought to examine the role of sex genotype in CNS tumour incidence and overall survival (OS). Methods Age-adjusted incidence and OS rates were collected from the Surveillance Epidemiology and End Result (SEER) registry between 2000 and 2011 for common paediatric ( Results The total cases are as follows: males=3018 and females=2276. Highest incidence was seen in PA (n=2103). GBM displayed the worst OS, whilst PA displayed the best. Higher incidence was observed in males for all tumours, except PA. Females with ependymoma had significantly better OS compared to males, whereas males with germinomas had better OS compared to females. Females Conclusion Interrogating population-based registries such as SEER minimises bias and provides credible data. Observed differences in incidence and OS between the sexes for different paediatric CNS tumours provide useful prognostic information for clinicians. Sex genotype was a significant independent prognostic factor in ependymomas and germinomas. Further investigation of possible epigenetic and hormonal differences may provide sex-specific vulnerabilities that may be exploitable for targeted therapy.
Databáze: OpenAIRE
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