The effect of six weeks topical nasal betamethasone drops on the hypothalamo-pituitary-adrenal axis and bone turnover in patients with nasal polyposis
| Autor: | J. J. Homer, D. B. Henson, Nick Jones, A. G. Gazis, S. R. Page |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Deoxypyridinoline Hypothalamo-Hypophyseal System Hydrocortisone medicine.drug_class Urinary system Anti-Inflammatory Agents Pituitary-Adrenal System Betamethasone Bone and Bones Bone remodeling chemistry.chemical_compound Nasal Polyps Internal medicine medicine Humans Nasal polyps Amino Acids Prospective cohort study Administration Intranasal Creatinine business.industry medicine.disease Alkaline Phosphatase Endocrinology Otorhinolaryngology chemistry Corticosteroid Female Bone Remodeling business hormones hormone substitutes and hormone antagonists Biomarkers medicine.drug |
| Zdroj: | Clinical otolaryngology and allied sciences. 24(6) |
| ISSN: | 0307-7772 |
| Popis: | Betamethasone topical nasal drops may have systemic corticosteroid activity and cause suppression of the hypothalamo-pituitary-adrenal (HPA) axis and impairment of bone turnover. The aim of this study was to assess the effect of a standard 6-week regime of betamethasone topical nasal drops on the HPA axis (using a physiological dose (1 microg) ACTH test) and on bone turnover (using markers of bone turnover, urinary deoxypyridinoline and serum bone specific alkaline phosphatase). Eleven patients with nasal polyposis were included in a prospective cohort study. Plasma cortisol was lower after betamethasone treatment at all time intervals (P < 0. 0001). There was no change in urinary deoxypyridinoline corrected for creatinine or bone specific alkaline phosphatase. Six weeks' treatment with recommended doses of betamethasone suppresses the HPA axis, but has no significant effect upon markers of bone turnover. Topical betamethasone in subjects with nasal polyps should be viewed as systemic corticosteroid administration and the long and short-term sequelae should be borne in mind. |
| Databáze: | OpenAIRE |
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