Dipeptide transport in isolated intestinal brush border membrane
| Autor: | Kristine Sigrist-Nelson |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Time Factors
Brush border Stereochemistry Glycine Biophysics Biological Transport Active Stimulation Biochemistry chemistry.chemical_compound Leucine Intestine Small Animals Mannitol Intestinal Mucosa Dipeptide Leucine transport Vesicle Cell Membrane Sodium Dipeptides Cell Biology Rats Kinetics Dipeptide transport chemistry |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Biomembranes. 394:220-226 |
| ISSN: | 0005-2736 |
| DOI: | 10.1016/0005-2736(75)90260-6 |
| Popis: | Transport of glycyl- l -leucine into isolated brush border membrane vesicles was studied. On the basis of the following observations it was postulated that glycyl- l -leucine was transported intact by a specific dipeptide mechanism. 1. (1) The differing time course and Na + stimulation of glycine, l -leucine and glycyl- l -leucine. 2. (2) The failure of glycine and l -leucine to inhibit glycyl- l -leucine transport. 3. (3) Initial presence of dipeptide within the vesicle. 4. (4) Inhibition of glycyl- l -leucine uptake by other dipeptides. 5. (5) The occurrence of accelerated amino acid uptake in the presence of the dipeptide. |
| Databáze: | OpenAIRE |
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