Positron emission tomography changes management and prognostic stratification in patients with oesophageal cancer: results of a multicentre prospective study
| Autor: | I. Ho Shon, Jayne Ramshaw, Andrew Patrikeos, Andrew M. Scott, Barry E. Chatterton, Nat Lenzo, Andrew Baldey, David Wong, Ben Kelley |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Fluorine Radioisotopes Esophageal Neoplasms Disease Prognostic stratification Disease-Free Survival Fluorodeoxyglucose F18 medicine Humans Radiology Nuclear Medicine and imaging In patient Prospective Studies Prospective cohort study Aged Neoplasm Staging medicine.diagnostic_test business.industry Cancer General Medicine medicine.disease Prognosis Open study Positron emission tomography Positron-Emission Tomography Orthopedic surgery Female Radiology Radiopharmaceuticals business Tomography X-Ray Computed |
| Zdroj: | European journal of nuclear medicine and molecular imaging. 36(3) |
| ISSN: | 1619-7089 |
| Popis: | The aims of this study were (1) to determine the incremental information provided by 18F-FDG positron emission tomography (PET) in staging patients with oesophageal cancer, and (2) to determine the impact of PET staging on post-PET clinical management of oesophageal cancer, and on prognosis. In a multicentre, single-arm open study, patients with proved oesophageal cancer without definite distant metastases and regarded as suitable for potentially curative treatment were examined by PET. Clinicians were requested to supply a management plan before and another plan after being supplied with the PET scan results. Patients were followed for at least 1 year for outcome analysis. A total of 129 patients (104 men, mean age 67 y) were recruited. PET detected additional sites of disease in 53 patients (41%). Significant changes in management (high or medium impact) were observed in 38% of patients, primarily as a result of identifying additional sites of disease and/or confirming previously equivocal regional and distant metastases. Progression-free survival was significantly shorter in patients found to have additional lesions on PET (p |
| Databáze: | OpenAIRE |
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